内皮单核细胞活化多肽Ⅱ与肿瘤

Endothelial monocyte-activating polypeptide- Ⅱ and tumor

内皮单核细胞活化多肽11（EMAP—Ⅱ）是一个致炎细胞因子，具有致炎、促凋亡和抗血管生成特性。EMAP-Ⅱ与肿瘤坏死因子（TNF）、血管内皮生长因子（VEGF）、低氧诱导因子1α（HIF-1α）、精氨酰-tRNA合成酶和胰岛素样生长因子-Ⅰ等多种肿瘤相关蛋白相互作用。EMAP-Ⅱ具有抗肿瘤特性，在肿瘤防治中具有应用前景。

Endothelial monocyte-activating polypeptide-Ⅱ （EMAP-Ⅱ ） is a novel proinflammatory cytokine with proinflammatory, proapoptotic and antiangiogenic properties. It is associated with many tumorassociated proteins, such as tumor necrosis factor, vascular endothelial growth factor, hypoxia inducible factor-1 α, arginyl-tRNA synthetase, and insulin-like growth factor- I EMAP-Ⅱ has anti-tumor properties and has a good prospect in cancer prevention and treatment.