摘要
凝血酶敏感蛋白-1(TSP-1)在多种肿瘤中表达,并通过诱导内皮细胞凋亡等机制抑制肿瘤血管生成,从而阻止肿瘤生长。其功能结构域(TypeI序列)3TSR保留了抑制新生血管形成的功能,在临床肿瘤治疗中具有一定的实际应用意义。
Thrombospondin-I expresses :in a variety of tumors and induces endothelial cell apoptosis, thus inhibits tumor angiogenesis and prevents tumor growth. It function domain (Type I sequence): 3TSR, retaines the function of inhibit angiogenesis , has the certain practical significance in clinical cancer treatment.
出处
《国际肿瘤学杂志》
CAS
2011年第11期823-826,共4页
Journal of International Oncology
关键词
凝血酶敏感蛋白1
血管生成抑制剂
细胞凋亡
3TSR
Thrombospondin 1
Angiogenesis inhibitors
Apoptosis
Three thrombospondin-1 type 1repeats