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凝血酶敏感蛋白-1在肿瘤中的研究进展 被引量:4

Thrombospondin-1 in cancer
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摘要 凝血酶敏感蛋白-1(TSP-1)在多种肿瘤中表达,并通过诱导内皮细胞凋亡等机制抑制肿瘤血管生成,从而阻止肿瘤生长。其功能结构域(TypeI序列)3TSR保留了抑制新生血管形成的功能,在临床肿瘤治疗中具有一定的实际应用意义。 Thrombospondin-I expresses :in a variety of tumors and induces endothelial cell apoptosis, thus inhibits tumor angiogenesis and prevents tumor growth. It function domain (Type I sequence): 3TSR, retaines the function of inhibit angiogenesis , has the certain practical significance in clinical cancer treatment.
作者 赵培雷 郭平
出处 《国际肿瘤学杂志》 CAS 2011年第11期823-826,共4页 Journal of International Oncology
关键词 凝血酶敏感蛋白1 血管生成抑制剂 细胞凋亡 3TSR Thrombospondin 1 Angiogenesis inhibitors Apoptosis Three thrombospondin-1 type 1repeats
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