干细胞介导溶瘤腺病毒治疗脑胶质瘤研究进展

Treatment of malignant gliomas with stem cells mediated oncolytic adenovirus

溶瘤腺病毒治疗具有肿瘤特异性、安全性和反复表达治疗基因等特点，通过溶瘤腺病毒治疗胶质细胞瘤已获得令人鼓舞的成果，但局部应用溶瘤腺病毒无法作用于散在分布的肿瘤细胞，影响了治疗效果。干细胞对脑胶质瘤具有内在趋化作用，介导溶瘤腺病毒治疗胶质瘤可进一步提高疗效。

Oncolytic adenoviruses are genetically altered to replicate within tumor cells while exhibiting a high degree of infectivity, good safety and specificity. The use of oneolytic adenoviruses to treat malignant brain tumors has been proved to be a promising mode of cancer therapy. Local injection of adenoviral vectors fails to reach scattered infiltrative tumor cells within the brain parenchyma and the therapeutic effect of intrac- ereberal injections of oncolytie adenoviruses is only seen in the vicinity of the injection site. To remedy this and prevent possible tumor recurrence, stem cells have been explored as vehicles for gene therapy in brain tumors given that they possess an intrinsic tropism for brain glioma.