摘要
环境内分泌于扰物是普遍存在于环境中的一类外源性化学物质，这些物质可干扰体内天然激素的合成、释放、转运、与受体结合、代谢及清除等各个方面，干扰正常激素维持体内平衡和调节发育过程的作用。环境内分泌干扰物被证实是引起儿童性分化、性发育异常的重要致病因素。环境内分泌干扰物可扰乱下丘脑-垂体-性腺轴，干扰雄激素的生物合成、转运、与受体结合、代谢和清除以及通过环境-基因的交互作用来影响儿童的性分化、性发育进程。
Environmental endoerine disruptors are pollutants of many exogenous chemical classes, which are ubiquitous and persistent in the environment and can interfere with the body＇s natural steroidogenesis, seeretion, transport, and reeeptnr binding, biotransformation and removal of other aspects, thus, they may disturb normal hormone maintaining the organism ＇s balanee and regulating development proeess. Therefore, exposure to these pollutants is one of the biggest factors that induce sex differentiation and sexual abnormality in children , which has been proved by many data from epidemiological researches. Environmental endocrine disruptors may influence the sexual differentiation and sexual development process of children by disturbing the hypothalamus-pituitary-gouadal axis and affecting the biosynthesis, transport, receptor binding, metabolism and clearance of androgen as well as interacting with genes.
出处
《国际儿科学杂志》
2011年第6期560-564,共5页
International Journal of Pediatrics
基金
基金项目：国家自然科学基金资助项目（30371820）
关键词
内分泌干扰物
性分化
性发育
Endocrine disruptors
Sexual differentiation
Sexual development
