生活方式干预对2型糖尿病病人一级亲属糖脂代谢影响

EFFECTS OF LIFE STYLE INTERVENTION ON GLUCOLIPID METABOLISM IN FIRST-DEGREE RELATIVES OF PATIENTS WITH TYPE 2 DIABETES

目的探讨生活方式干预对2型糖尿病病人一级亲属糖、脂代谢的影响。方法对105例糖耐量正常的2型糖尿病病人一级亲属实施生活方式干预1年,比较干预前后的体质量(BW)、体质量指数(BMI)、腰围(WC)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FBG)、血胰岛素水平(FINS)、胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)的变化。结果与干预前比较,干预后BW、BMI、WC、SBP、DBP、FBG、FINS、HOMA-IR、TG、TC及LDL均明显降低,差异有显著性(t=8.053～13.980,P<0.01)。结论生活方式干预可明显改善2型糖尿病病人一级亲属的糖、脂代谢。

Objective To investigate the effects of life style intervention on glucose and lipid metabolism in first-degree relatives of patients with type 2 diabetes.Methods Life style intervention was given to 105 normal glucose tolerant first-degree relatives of patients with type 2 diabetes for one year.Body weight（BW）,body mass index（BMI）,waist circumference（WC）,systolic pressure（SP）,diastolic pressure（DP）,fasting blood glucose（FBG） and FINS,total cholesterol（TC）,triacylglycerol（TG）,low density lipoprotein（LDL） and HOMA-IR were measured,before and after intervention,and compared.ResultsThe levels of BW,BMI,WC,SBP,DBP,FBG,FINS,HOMA-IR,TG,TC and LDL were significantly lower after intervention than before（t=8.053-13.980,P0.01）.Conclusion Lifestyle intervention can significantly improve glucose and lipid metabolism in first-degree relatives of patients with type 2 diabetes.