来曲唑对肥胖和非肥胖型PCOS病人促排卵的影响

THE EFFECT OF LETROZOLE ON OVARIAN STIMULATION IN PATIENTS WITH OBESE OR NON-OBESE POLYCYSTICOVARIAN SYNDROME

目的探讨来曲唑(LE)对肥胖型和非肥胖型多囊卵巢综合征(PCOS)病人促排卵影响。方法选择40例PCOS不孕病人,根据体质量指数(BMI)分为肥胖型组和非肥胖型组,两组均于月经或黄体酮撤退性出血第3～7天给予LE 2.5mg/d口服治疗,随后阴道B超监测卵泡发育情况,当最大卵泡平均直径≥18mm时,肌注人绒毛膜促性腺激素(HCG)10 000U诱导排卵,并记录HCG注射日直径≥18mm卵泡数和子宫内膜厚度,分别统计排卵率和妊娠率。结果两组HCG注射日卵泡数和子宫内膜厚度比较差异无显著性(P>0.05),两组单卵泡率、排卵率和妊娠率比较差异无显著性(P>0.05)。结论 LE对肥胖型和非肥胖型PCOS病人促排卵效果相似。

Objective To study the effect of letrozole（LE） on ovarian stimulation in obese and non-obese patients with polycystic ovarian syndrome（PCOS）.Methods Forty infertile women with PCOS were selected and divided into obese and non-obese groups based on body mass index（BMI）.At days 3-7 of menstruation or progesterone-withdrawal bleeding,oral LE of2.5 mg/d was given,and vagina sonography was followed to monitor the development of follicle.When the diameter of the biggest follicle reached 18 mm,10 000 U of HCG was injected to trigger ovulation.The numbers of follicle reaching the diameter of ≥18 mm and the thickness of endometrium on the day of HCG injection were recorded.Ovulation rate and pregnancy rate were added up,respectively.Results The differences of number of follicle and the thickness of endometrium on the day of HCG injection were not significant between obese and non-obese groups（P0.05）,and that were also not significant between them in terms of rates of single follicle,ovulation and pregnancy（P0.05）.Conclusion The effect of LE on ovarian stimulation is similar in obese and non-obese patients with PCOS.