胰腺癌组织Syndecan-1与E-cadherin表达及意义

EXPRESSIONS OF Syndecan-1 AND E-cadherin IN PANCREATIC CANCER AND THEIR CLINICAL SIGNIFICANCE

目的探讨Syndecan-1和E-cadherin在胰腺癌组织中的表达及其临床意义。方法采用免疫组织化学PV6000法检测47例胰腺癌组织和10例正常胰腺组织中Syndecan-1及E-cadherin的表达。结果 10例正常胰腺组织中Syndecan-1均呈阴性表达,而E-cadherin均为阳性表达。胰腺癌组织中Syndecan-1和E-cadherin的表达阳性率分别为44.7%和46.8%,二者均与胰腺癌的分化程度、有无淋巴结转移和临床分期有关（χ2=6.01~9.75,P〈0.05）,与病人性别、年龄、肿瘤大小和1年生存期无关（χ2=0.28~3.63,P〉0.05）。结论 Syndecan-1和E-cadherin在胰腺癌的发生发展中起重要作用,其表达水平可作为判断胰腺癌生物学行为的参考指标。

Objective To investigate the expressions and clinical significance of Syndecan-1 and E-cadherin in pancreatic carcinoma. Methods Expressions of Syndecan-1 and E-cadherin were detected by immunohistochemical PV 6000 technique in 10 normal pancreatic tissues and 47 pancreatic carcinoma tissues. Results In normal pancreatic tissue,the expression of Syndecan-1 was negative,and that of E-cadherin was positive.In the cancer tissue,the expressions of Syndecan-1 and E-cadherin were44.7% and 46.8%,respectively,both the expressions were correlated with cell differentiation,with or without lymph-node metastasis,and clinical staging（χ2=6.01-9.75,P〈0.05）,but not related to gender,age of patient,tumor size and one-year survival（χ2=0.28-3.63,P〉0.05）. Conclusion Syndecan-1 and E-cadherin play an important role in the occurrence and development of pancreatic cancer,the expressions of these two markers can be used as a reference index to judge the biological behaviour of the cancer.