妊娠糖尿病病人血清FABP4的变化及意义

CHANGES OF SERUM ADIPOCYTE FATTY ACID BINDING PROTEIN LEVELS IN GESTATIONAL DIABETES MELLITUS

目的观察妊娠糖尿病（GDM）病人血清脂肪细胞脂肪酸结合蛋白（FABP4）的含量变化,探讨其与GDM发病的关系。方法 2008年5月—2009年4月,选择在我科行择期剖宫产术的GDM孕妇30例为GDM组,以同期行选择性剖宫产术的糖耐量正常孕妇30例为对照组。采用酶联免疫吸附法检测两组孕妇血清FABP4水平,放射免疫法检测空腹胰岛素（FINS）水平,葡萄糖氧化酶法检测空腹血糖（FBG）水平,计算稳态模型的胰岛素抵抗指数（HOMA-IR）,并对GDM组孕妇血清FABP4水平与HOMA-IR行相关性分析。结果 GDM组孕妇血清FABP4、FINS、FBG水平及HOMA-IR均显著高于对照组（t=5.80~23.01,P〈0.05）。GDM组孕妇血清FABP4水平与HOMA-IR呈显著相关性（r=0.595,P〈0.05）。结论 GDM孕妇血清中FABP4水平升高可能与GDM发病有关。

Objective To investigate the changes of serum adipocyte fatty acid binding protein（FABP4） in gestational diabetes mellitus（GDM）. Methods This study consisted of 30 GDM patients who underwent Caesarean section,during May2008-April 2009 period,were assigned to GDM group,and 30 normal pregnant women who received Caesarean section in the same period were enrolled as control group.Serum FABP4 levels of pregnant women in the two groups were detected by enzyme-linked immunosorbent assay（ELISA）;fasting insulin（FINS） levels were detected by radioimmunity assay;fasting blood glucose（FBG） was measured by glucose oxidase method.Insulin resistance index（HOMA-IR） was calculated according to equations.A correlation between FABP4 and HOMA-IR was analyzed. Results The serum levels of FABP4,FINS,FBG and HOMA-IR in GDM group were significantly higher than that in the control（t=5.80-23.01,P〈0.05）.The level of serum FABP4 in GDM group was positively correlated with HOMA-IR（r=0.595,P〈0.05）. Conclusion The elevation of serum FABP4 in GDM is probably associated with the pathogenesis of this disease.