摘要
目的探讨人着色性干皮病G组(XPG)及谷胱甘肽巯基转移酶P1(GSTP1)基因多态性与晚期胃癌以奥沙利铂为主的化疗敏感性的关系。方法 80例Ⅳ期胃癌病人化疗前采集外周静脉血,提取DNA,用实时荧光PCR技术检测XPG C46T及GSTP1 A105G基因的单核苷酸多态性(SNP)分型,比较不同基因型与化疗效果的关系。结果 80例病人XPG C46T基因C/C与T/T+C/T及GSTP1 A105G基因A/A与A/G+G/G基因型化疗有效率比较差异均有显著意义(χ2=5.459、5.291,P<0.05)。同时携带XPG C46T C/C和GSTP1 A105G A/G+G/G基因型病人化疗敏感性是同时携带XPG C46T C/T+T/T和GSTP1 A105G A/A基因型病人的4.886倍(OR=4.886,P<0.05)。结论 XPG C46T、GSTP1 A105G基因多态性可能与晚期胃癌病人接受以奥沙利铂为主一线化疗药物化疗后的效果有关。
ObjectiveTo research the correlation of xeroderma pigmentosum group G（XPG） and glutathione S transferase P1（GSTP1） gene polymorphisms with sensitivity to oxaliplatin-based chemotherapy in advanced gastric cancer（AGC）.MethodsDNA was extracted from peripheral venous blood of 80 AGC patients,XPG C46T and GSTP1 A105G genotypes were detected with real-time PCR.A relationship between different genotypes and chemotherapeutic efficacy（CE） was compared.ResultsThe differences of the CE between patients with XPG C46T gene C/C and C/T＋T/T genotype,GSTP1 A105G A/A gene and A/G＋G/G genotype were significant（χ2=5.459,5.291;P0.05）.The sensitivity to the therapy in patients with simultaneous XPG C46T C/C and GSTP1 A105G A/G＋G/G genotypes was 4.886 times higher than that with XPG C46T C/T＋T/T and GSTP1 A105G A/A genotypes（OR=4.886,P0.05）.ConclusionThe gene polymorphisms of XPG C46T and GSTP1 A105G are likely to be associated with chemotherapeutic effects in patients with late gastric cancer after receiving first-line oxaliplatin therapy.
出处
《齐鲁医学杂志》
2011年第5期390-392,共3页
Medical Journal of Qilu
基金
山东省自然科学基金资助项目(Y2008C126)
