妊娠期妇女葡萄糖筛查2870例结果临床分析

GLUCOSE SCREENING IN WOMEN DURING GESTATION PERIOD: CLINICAL ANALYSIS OF 2870 CASES

目的初步了解本地区妊娠期糖尿病（GDM）的患病率,探讨不同孕期妇女的50 g葡萄糖负荷试验（GCT）对筛查GDM的临床意义,以及GDM与孕妇伴随有高危因素和孕期的关系。方法 2010年1—12月,来我院行葡萄糖筛查孕妇2 870例,按不同孕期分为孕24~28周组、孕〉28周组;按其是否伴有高危因素分为伴高危因素组、无高危因素组。进行分组对照研究。结果妊娠伴有高危因素的孕妇GCT和75 g口服葡萄糖糖耐量试验（OGTT）的异常检出率明显高于妊娠无高危因素组,两组比较差异有统计学意义（χ2=63.52、109.51,P〈0.05）;而不同孕周两组比较差异无统计学意义（χ2=1.00、0.27,P〉0.05）。结论本地区GDM有一定的患病率,伴有高危因素的孕妇GDM发生率高。对伴有高危因素的孕妇应尽早进行GCT筛查,对临床早期诊断、治疗GDM、改善妊娠结局具有重要意义。

ObjectiveTo understand the prevalence of gestational diabetes mellitus（GDM） in this locality,explore the significance of 50 g glucose stress test（GST） in screening GDM,and relationship between GDM and pregnant women with high risk factors and gestational period.MethodsGlucose screening was done in 2 870 pregnant women in our hospital during Jan-Dec.of 2010.Based on gestation period,they were divided into 24-28-week group and over-28-week group;based on whether there were risk factors,they were divided into with-risk-factor group and without-risk-factor group,a control study was conducted.ResultsThe GST and 75 g oral glucose tolerance test（OGTT） in pregnant women with high risk factors were significant higher than those without high risk factors,the difference between them being significant（χ2=63.52,109.51;P0.05）;and that difference between the two groups of different gestation week was not significant（χ2=1.00,0.27;P0.05）.ConclusionThere is a prevalence of GDM in this locality,with higher incidence in those with high risk factors.GST should be conducted in pregnant women as early as possible.Early diagnosis and treatment for GDM is of great significance for improving pregnancy outcome.