过敏性紫癜病人血清TGF-β_1和HGF水平的变化

CHANGES OF SERUM TGF-β_1 AND HGF IN PATIENTS WITH HENOCH-SCHONLEIN PURPURA

目的研究转化生长因子-β1（TGFβ-1）和肝细胞生长因子（HGF）在过敏性紫癜（HSP）病人血清中的表达及其在HSP发生发展中的作用。方法采用双抗体夹心酶联免疫吸附试验（ELISA）方法检测38例HSP病人（其中13例并发肾脏损害）和20例正常对照者血清TGFβ-1和HGF水平。结果两组HSP病人血清TGFβ-1和HGF水平明显均高于正常对照组（F=4.85、6.43,q=2.86~5.42,P〈0.05）,并发肾脏损害组血清TGF-β1和HGF水平明显高于无肾脏损害组（q=3.27、3.34,P〈0.05）。结论 TGFβ-1和HGF与HSP的发生发展有关,检测血清TGFβ-1和HGF水平有助于了解病情进展,判断预后。

Objective To study the expressions and effects of TGF-β1 and HGF in patients with Henoch-Schonlein purpura（HSP）.Methods The Serum levels of TGF-β1 and HGF were measured with enzyme linked immunosorbent assay in 38 patients with HSP（13 patients followed by renal damage） and 20 normal controls.Results Serum levels of TGF-β1 and HGF in HSP patients were higher than that in normal controls（F=4.85,6.43;q=2.86-5.42;P0.05）,and that in HSP patients with renal damage were higher than that in patients without（q=3.27,3.34;P0.05）.Conclusion TGF-β1 and HGF are related to the pathogenesis and development of HSP.Detection of serum TGF-β1 and HGF is conducive to understanding the progress of the condition and predicting its prognosis.