摘要
前药可改变药物的理化性质,如可降低毒性、增加水溶性、提高药物靶向性和生物利用度等。本文综述了近年来解热镇痛抗炎药、降压药、抗肿瘤药等类别中的儿个前体药物在透皮给药中的应用。
The prodrugs can change the physicochemical properties of drugs, such as reducing toxicity, enhancing water solubility, improving target and increasing bioavailability. The applications of several prodrugs in the therapeutic categories including antipyretic, analgesic, anti-inflammatory, antihypertensive and antineoplastic agents are reviewed.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2011年第8期636-639,I0002,共5页
Chinese Journal of Pharmaceuticals
关键词
前体药物
经皮给药系统
应用
综述
prodrug
transdermal delivery system
application
review
