摘要
骨髓微血管在血液系统疾病的发生发展中具有重要作用,其形成受多种调控因子的交互影响。目前在多种恶性血液病及非恶性血液病均发现存在血管生成的异常,骨髓微血管密度可作为判断疾病预后的重要指标,并在部分疾病中具有分层意义。通过给予相应的治疗,抑制或促进血管新生对提高疾病疗效具有重要意义,但部分疗效机制仍有待于深入探讨。
Sununary：Bone marrow microvessel plays an important role in the development and progression of hemato- logic diseases, and is regulated by a variety of regulatory factors. Since abnormal angiogenesis has been shown in a number of malignant and non-malignant hematologic diseases, microvessel density can be valuable as a prognostic indicator, and also as a stratifying factor in some of these diseases. In some cases, inhibiting or stimulating anglo- genesis with certain treatment may seem important in improve the outcomes. However, mechanisms underlying these effects are yet to be further investigated.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2011年第11期871-873,共3页
Chinese Journal of Practical Internal Medicine
基金
浙江省中医药重大疾病科技创新平台科研专项(2009ZDJB01)
中医药行业科研专项(NO.201107001)
关键词
骨髓微血管
血液病
调控因子
bone marrow microvessel
hematologic diseases
regulatory factor
