足月儿湿肺的临床特点及病情轻重影响因素的研究

Study on the clinical features and the related factors of transient tachypnea of newborn(TTN) in term infants

目的:分析比较足月儿湿肺临床特点及病情轻、重组的影响因素。方法:对吉林大学新生儿疾病诊治中心收治的足月儿湿肺患儿744例的基本资料、围产期因素、临床表现、辅助检查、治疗情况等进行回顾分析,并根据是否应用呼吸支持分为病情重组及病情轻组,分析比较影响病情轻、重的因素。结果:湿肺患儿以男性为主占67.1%,选择性剖宫产占61.8%,存在妊娠并发症者共447例占60.1%;入院呼吸频率≥60次/min 363例占48.8%,存在呼吸系统并发症者78例占10.5%。病情轻、重组间分娩方式、妊娠并发症、呼吸系统并发症及入院呼吸频率差异均有统计学意义(P<0.05)。结论:男性患儿、妊娠并发症、选择性剖宫产可能为湿肺发生的危险因素,妊娠并发症、选择性剖宫产、呼吸系统并发症可能为足月儿病情严重的危险因素,入院呼吸频率高可能为足月儿湿肺病情严重的预测因素。

Objective：To analyze the clinical features and the related factors of transient tachypnea of the newborn（TTN） in term infants.Methods：Some information of 744 term infants diagnosed with TTN at Neonatal Treatment Center of Jilin University were analyzed in the study,including the basic information,perinatal factors,clinical manifestations,accessory examination and therapy of them.Further more,they were divided into mild group and severe group depending to whether application of respiratory support,and the factors related severity of disease were analyzed.Results：Male infants were more（67.1%）,and elective caesarean section was 61.8%.447 cases（60.1%） had pregnancy complications;78 cases（10.5%） with respiratory complications,the initial respiratory rate of 363 cases（48.8%） were more than 60 times per minute.The delivery mode,pregnancy complications,respiratory complications and initial respiratory rate were all significantly difference（P0.05） between the mild and severity group.Conclusion：Male gender,perinatal complications,elective caesarean section may be the risk factors of TTN.Perinatal complications,elective caesarean section and respiratory complications may be the severity related factors of TTN in term infants.Initial respiratory rate may be the predictive factor of aggravation of the disease.