辅助生殖技术治疗后流产相关因素分析

Analysis of the correlation factors of spontaneous abortion after treatment by assistive reproductive technologies

目的:探讨辅助生殖技术(ART)治疗后自然流产的发生率及相关因素。方法:回顾性分析2007年1月～2008年6月在湖北省妇女儿童医院生殖医学中心接受ART治疗后222例妊娠患者的临床资料,了解体外受精-胚胎移植(IVF-ET)、单精子卵浆内显微注射(ICSI)的自然流产情况,比较未流产及流产组的年龄、既往自然流产史、不同促排方案的流产率、使用促排卵药物(Gn)的天数及用量、hCG日的子宫内膜厚度。结果:IVF及ICSI的自然流产率比较差异无统计学意义(P>0.05),不同促排方案间的流产率差异无统计学意义(P>0.05),流产组与对照组患者平均年龄比较差异有统计学意义(P<0.05),流产组既往有流产史者明显高于未流产组(P<0.05),流产组hCG日子宫内膜厚度显著低于对照组(P<0.05)。结论:引起ART早期妊娠丢失的原因复杂,可能与患者既往妊娠史、年龄、子宫内膜厚度等因素相关。

Objective：To analyze the incidence and correlation factors of spontaneous abortion after treatment by assistive reproductive technologies（ART） Methods：The data of 222 pregnancies who had treated by ART in our hospital from January 2007 to June 2008 were analyzed retrospectively.The patients were divided into abortion group and delivery group according to the pregnancy outcome.Then to know the condition of pregnancy loss in vitro fertilization-embryo transfer（IVF-ET） and introcytoplasmic sperm injection.The abortion history,treatment project,ICSI program,age,thickness of endometrium on day of human chorionic gonadotrophin administration（hCG）,and number of gonadotrophin used were evaluated.Results：The natural abortion rates of IVF and ICSI in the two groups were not statistically significant（P0.05）.The patients who had a history of ectopic pregnancy or spontaneous abortion had a higher early pregnancy loss rate.The average age in abortion group was significantly higher than in delivery group（P0.05）.The thickness of endometrium on the day of hCG in abortion group were thinner than that in control group..Conclusion：The factors related to early pregnancy loss in IVF-ET are very complicated.The abortion history,age and the thickness of endometrium on the day of hCG are the important factors related to the early pregnancy loss