摘要
目的:探讨环氧合酶-2(cyclooxygenase-2,COX-2)和人乳头瘤病毒16型E6蛋白(human papillomavirus-16 E6 protein,HPV16-E6)在宫颈癌中的表达及其与临床病理特征之间的关系。方法:采用免疫组化S-P法检测COX-2和HPV16-E6蛋白在宫颈癌上皮中的阳性表达情况。结果:COX-2与淋巴结转移、宫旁或脉管浸润及肌层浸润深度呈显著性相关(P<0.05)。HPV16-E6与年龄、病理类型、宫旁或脉管浸润呈显著性相关(P<0.05)。COX-2和HPV16-E6蛋白在宫颈癌中的阳性率呈正相关(P<0.01)。结论:COX-2和HPV16-E6在宫颈癌的侵袭转移中可能发挥协同作用。联合应用选择性COX-2抑制剂和HPV疫苗是宫颈癌防治中的一个新的有效策略。
Objective：To investigate the expression of COX-2 and HPV16-E6 in the occurrence and development of cervical cancer.Methods：The expression of COX-2 and HPV16-E6 protein was examined with immunohistochemistry.Results：The positive expression of COX-2 was associated with lymph node metastasis,infiltration of latero-uterus or haemal tube and infiltrative depth of muscle（P0.05）.The positive expression of HPV16-E6 was associated with the age of the patients,pathological types and the infiltration of latero-uterus or haemal tube（P0.05）.The expression of COX-2 and HPV16-E6 protein were positively related in cervical cancer（P0.01）.Conclusion：COX-2 and HPV16-E6 produce possibly a synergistic effect to the invasion and metastasis in cervical carcinoma.To apply COX-2 selective inhibitor combined with vaccine of HPV is valid strategy in prevention and treatment of cervical carcinoma.
出处
《中国妇幼保健》
CAS
北大核心
2011年第32期5062-5066,共5页
Maternal and Child Health Care of China
