口腔颌面病术前肌注盐酸戊乙奎醚对血压心率和腺体分泌影响的研究

The effect of muscular penehycliedine hydrochloride injection on heart rate and blood pressure of preoperative oral and maxillofacial patients

目的比较盐酸戊乙奎醚和阿托品用作口腔手术患者术前用药的临床效果。方法选择河南大学淮河医院2004年8月至2007年10月收治的100例美国麻醉医师协会(ASA)分级Ⅰ～Ⅱ级择期全麻下行口腔颌面外科手术患者,随机分为两组,Ⅰ组(盐酸戊乙奎醚组)和Ⅱ组(阿托品组),每组50例。两组患者分别于三角肌注射盐酸戊乙奎醚0.01mg/kg和阿托品0.01mg/kg,观察注药后10min、20min和30min的血压、心率,用视觉模拟评分(VAS)测定口干程度,手术结束后评估恢复期口干和腺体分泌情况。结果两组患者肌注盐酸戊乙奎醚或阿托品后30min内收缩压、舒张压与注药前比较差异均无统计学意义;阿托品组对心率的影响明显,以肌注后20min至30min最为明显,与注药前及盐酸戊乙奎醚组比较差异有统计学意义;两组注药后均有口干,但两组间差异无统计学意义。结论盐酸戊乙奎醚不影响血压和心率,是口腔颌面手术麻醉前用药的更佳选择。

Objective To compare the clinical effects of penehycliedine and atropine on preoperative oral and maxillofacial patients.Methods 100 ASA I～Ⅱoral and maxillofacial surgery patients were randomly divided into two groups:group I(penehycliedine group)and groupⅡ(atropine group),each group with 50 patients.The patients of each group were medicated at triangularis muscle with 0.01 mg/kg penehycliedine or 0.01 mg/kg atropine respectively,heart rate and blood pressure were observed for 10 min,20 min,and 30 min.The dryness of mouth was surveyed with VAS,and the conditions of dry mouth and gland secretion during convalescence after operation were assessed.Results There was no obvious change appeared in the heart rate or blood pressure of the patients in group I(P>0.05).While the heart rate and blood pressure of the patients in group II increased significantly compared to the basal value especially in 20 and 30 min after medication,which is significantly different from group I(P<0.05),but there was no obvious change in the blood pressure(P>0.05).Conclusion Penehycfiedine does not affect blood pressure or heart rate.Penehycliedine can be injected safely among preoperative oral and maxillofacial patients.