HSP70在宫颈尖锐湿疣和鳞癌中的表达

Expression of HSP70 in cervical condyloma accuminatum and cervical squamous cell carcinoma

目的探讨热休克蛋白70(HSP70)与宫颈尖锐湿疣(CA)和鳞癌发病的关系。方法应用免疫组织化学S-P法检测40例宫颈CA、40例宫颈鳞癌及10例正常宫颈组织中HSP70的表达。结果HSP70在宫颈鳞癌、宫颈CA、正常宫颈组织中的阳性表达率分别为70%、50%、20%,宫颈鳞癌显著高于正常宫颈、宫颈CA,差异有统计学意义(均P<0.05);且与宫颈鳞癌临床分期、有无淋巴结转移呈正相关(均P<0.05)。结论HSP70在宫颈鳞癌中高表达,提示HSP70可能参与了宫颈病变过程。

Objective To investigate the expression and signif icance of HSP70 in cervical condyloma accuminatum and cervical squamous cell carcinoma.Methods Immunohistochemical S-P method was used to detect the expression of HSP70 in the cervical epithelial tissue from 40 cases of cervical condyloma accuminatum and 40 cases of cervical squamous cell carcinoma.10 healthy females served as the control.Results The expression of HSP70 in the tissue of cervical squamous cell carcinoma was signif icantly stronger than in the tissue of cervical condyloma accuminatum and normal cervical tissue(P<0.05).The expression of HSP70 was positively related to the clinical stages of cervical squamous cell carcinoma and lymphatic metastasis(P<0.05).Conclusion HSP70 overexpression may play an important role in the development of cervical squamous cell carcinoma.