免疫调节治疗在老年重症肺炎患者中的意义

Immunity regulation treatment in old patients with severe pneumonia

目的:评价胸腺肽α1联合乌司他丁对老年重症肺炎患者免疫功能的影响。方法:将28例患者随机分成治疗组和对照组,治疗组在常规治疗基础上加胸腺肽α1和乌司他丁,对照组采用常规治疗,观察两组患者治疗前后CD细胞和自然杀伤(NK)细胞及APACHEⅡ评分水平、炎症反应指标和血气分析变化。结果:与对照组比较,治疗组CD^+4、CD^+8及NK细胞水平显著升高(P<0.01),APACHEⅡ评分显著下降(P<0.05),炎症反应指标(P<0.05)和血气分析也显著改善(P<0.01)。结论:胸腺肽α1联合乌司他丁治疗老年重症肺炎可提高患者的细胞免疫功能,抑制过度炎症反应。

[Objective]To investigate the effects of thymosin- a1 combined ulinastatin on immunity in old patients with sever pneumonia.[Method]28 patients were divided into two group randomly;therapy group and control group.The control group was give routine therapy while the therapy group was given routine therapy,thymosin - aland ulinastatin.the scores of APACHEⅡand the number of CD cells and NK cells were recorded.[Result]Number of CD + 4 cells,CD + 8 cells and NK cells in therapy group increased significantly(P < 0.01) while the score of APACHEⅡand index for inflammatory reaction decreased significantly compared with the control group(P < 0.05).[Conclusion] Thymosin-a1 combined ulinastatin can help to improve the immunity of old patients with severe pneumonia,attenuate the excess inflammatory response of sepsis.