2型糖尿病患者血清hsCRP、TNF-α及IL-6的表达及相关性分析

Correlation Analysis and Expression of hsCRP,TNF-α and IL-6 in the Serum of Type 2 Diabetic

目的分析高敏C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)在2型糖尿病患者血清的表达及相关性,探讨它们在2型糖尿病发病过程中的作用及意义。方法分别测定32例健康人群(对照组)和32例2型糖尿病患者(实验组)血清hsCRP、TNF-α、IL-6水平,并采用SPSS13.0软件对实验数据进行统计分析。结果对照组hsCRP、TNF-α、IL-6的血清浓度值明显低于实验组,两者之间的差异十分显著(P=0.000)。实验组hsCRP、TNF-α、IL-6三者之间存在明显相关性。结论hsCRP、TNF-α、IL-6在2型糖尿病患者血清中明显增高且存在明显相关。提示三者可能参与了2型糖尿病的发病过程,其检测对2型糖尿病的诊断和预后具有潜在的临床价值。

Objective To analyze the expression and the correlation of high sensitivity C-reactive protein (hsCRP),tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in the serum of the patients with type 2 diabetic and explore the clinical significance in the diagnosis and prognosis of type 2 diabetic. Methods The expression level of hsCRP and TNF-α and IL-6 in the serum samples from 32 healthy people who were as control group and 32 type 2 diabetic patients who were as experimental group were detected. The data was analyzed by using the SPSS 12.0 software. Results The concentration of hsCRP and TNF-α and IL-6 in the control group was obvious lower than that of the experimental group. There was statistics significance between the two groups (P=0.000). The expression levels of hsCRP and TNF-αand IL-6 of the serum showed close correlation with each other in the experimental group. Conclusion The expression level of hsCRP and TNF-α and IL-6 in the serum of type 2 diabetic patients were not only higher than them in the serum of health people,but demonstrated positive correlation with each other. The results show that hsCRP and TNF-α and IL-6 may be involved in the pathogenesis of type 2 diabetic,and maybe have potential clinical values in the diagnosis and prognosis of type 2 diabetic.