支气管激发试验对咳嗽变异型哮喘的临床诊断价值及其评价

Evaluation and diagnosis value of bronchial provocation test in patients with chronic cough

目的探讨支气管激发试验(BPT)在慢性咳嗽及咳嗽变异型哮喘(CVA)诊断中的价值。方法对1155例慢性咳嗽患者进行乙酰甲胆碱支气管激发试验,检测其气道高反应性。结果1155例慢性咳嗽患者中,各年龄组肺功能参数比较无显著差异。BPT阳性584例,阴性571例,阳性率50.6%。确诊为CVA547例;其余37例BPT阳性慢性咳嗽患者中25例为感染后咳嗽,12例为慢性支气管炎。BPT诊断CVA的特异度为93.9%。小于30岁年龄组CVA比例最高,占慢性咳嗽68.8%;大于60岁的老年入CVA百分比最低,为23.5%。结论CVA是慢性咳嗽的主要病因,对不明原因的慢性咳嗽患者应及时进行BPT,有助于早期明确诊断并施以正确治疗。

Objective To investigate the etiological diagnosis utilization value of bronchial provocation tes(tBPT) in patients with chronic cough variant asthma(CVA) .Methods The bronchial provocation test was performed to assess the bronchial responsiveness by inhaling methacholine in 1155 patients with chronic cough.RESULTS There was no significant difference of pulmonary function in vary age groups.The positive rate of bronchial provocation test was 50.6%(584/1155,285 males,299 females,In those patients with positive result,547 patients were diagnosed as CVA,25 patients as post-infection cough,and 12 patients as chronic bronchitis.Spe-cificity of BPT was 93.9%.The population under 30 years had the highest CVA diagnostic rate of 68.8%and those over 60 years had the lowest diagnostic rate of 23.5%.These two groups had significant difference when compared to the other age groups respectively.Conclusions CVA is the main cause of chronic cough.The BPT is a simple and effective method in the diagnosis of CVA at early stage.