胆汁反流与幽门螺杆菌感染和消化性溃疡的关系

Relation of bile reflux with Helicobacter pylori infection and peptic ulcer

目的探讨胆汁反流与消化性溃疡和幽门螺杆菌感染的关系。方法选择行胃镜检查的患者400例,并同时行幽门螺杆菌检测。根据胃镜下是否存在胆汁反流分为胆汁反流阳性组和胆汁反流阴性组,比较两组间幽门螺杆菌感染率和消化性溃疡的发生率。结果胆汁反流阳性组消化性溃疡发生率9.88%(8/81),胆汁反流阴性组22.26%(71/319),胆汁反流阳性组消化性溃疡发生率低于胆汁反流阴性组(P<0.05);胆汁反流阳性组幽门螺杆菌感染率30.86%(25/81),胆汁反流阴性组51.72%(165/319),胆汁反流阳性组幽门螺杆菌感染率明显低于胆汁反流阴性组(P<0.01)。结论胆汁反流可能通过抑制幽门螺杆菌感染而减少了消化性溃疡的发生。

Objective To evaluate the relation of bile reflux and Helicobacter pylori infection and peptic ulcer.Methods400 patients with examination of gastro-endoscope were elevated.Bile reflux was determined by examination of gastro-endoscope.The ratio of Hp infection and peptic ulcer was compared between patients with bile reflux and patients with non bile reflux.ResultsThe ratio of peptic ulcer in patients with bile reflux(9.88%,8/81cases)was decreased as compared with that of peptic ulcer in patients with non bile reflux(22.26%,71/319cases)(P <0.05),The ratio of Hp infection in patients with bile reflux(30.86%,25/81cases)was significantly decreased as compared with that of Hp infection in patients with non bile reflux(51.72%,165/319cases)(P <0.01).ConclusionBile reflux may decrease onset of peptic ulcer by restraining Hp infection in patients with bile reflux.