血清D-乳酸水平变化与急性胰腺炎病情关系临床初探

Investigation of clinical relationship between the different state of acute pancreatitis and the change of serum D-lactic acid

目的探讨急性胰腺炎(AP)患者病情轻重与血清D-乳酸水平的关系,试图以血清D-乳酸水平作为评价AP病情轻重的指标。方法通过对62例AP患者的临床资料进行前瞻性分析,将其分为轻型急性胰腺炎(MAP)42例和重症急性胰腺炎(SAP)20例,另取30例健康正常人为对照组。选定血清D-乳酸作为监测肠道屏障功能的指标,并分析不同AP的病情严重程度与血清D-乳酸水平变化间的关系。结果62例AP患者血清D-乳酸水平明显高于正常对照组(P<0.05);SAP患者血清D-乳酸水平明显高于MAP患者(P<0.05)。结论肠道通透性变化与AP病情轻重关系密切,不同病情AP患者血清D-乳酸水平不同。血清D-乳酸水平可以作为评价AP病情轻重程度的实验室指标。

Objective To investigate the clinical relationship between the different state of acute pancreatitis (AP) and the change of serum D-lactic acid, attempt to use the level of serum D-lactie acid to evaluate the severity of AP. Methods A prospective analysis was made in 62 patients with AP, by dividing the patients into mild acute pancreatitis(MAP) group with 42 cases and severe acute pancreatitis(SAP) group with 20 cases, 30 healthy people were selected as control group. The change of serum D-lactic acid was selected to observe, relationship between the different state of AP and the change of serum D-lactic acid was analyzed. Results The serum D-lactic acid of AP group was higher than that of control group (P<0.05), and the Serum D-lactic acid of SAP group was obviously higher than that of MAP group (P<0.05). Conclusion Relationship between gut barrier and the state of AP is close, the different state of AP has the different level of serum D-lactic acid, serum D-lactic acid can be used as a laboratory reference to forecast the severity of AP.