去白细胞红细胞悬液在弥散性血管内凝血治疗中的研究与应用

Study and application of LPRC in treating DIC

目的:研究去白细胞红细胞悬液在弥散性血管内凝血(DIC)治疗中的作用。方法:用去白细胞红细胞悬液和新鲜冰冻血浆联合输注进行临床观察,并与新鲜全血的临床效果进行比较,同时检测当天和储存3d的新鲜全血以及7d内去白细胞红细胞悬液中组织型纤溶酶原激活物(t-PA)的活性,以旁证去白细胞红细胞悬液在DIC治疗中的作用。结果:当天和储存3d的新鲜全血,以及7d内去白细胞红细胞悬液中t-PA的活性,三者间t-PA活性差异无统计学意义。用7d内去白细胞红细胞悬液和新鲜冰冻血浆代替当天新鲜全血抢救DIC患者可取得同等效果。结论:7d内去白细胞红细胞悬液中t-PA的活性与当天新鲜全血差异无统计学意义,抢救DIC时不必要强调输注新鲜全血,只要合理输注成分血,效果等同于新鲜全血。

Objective:To study the effect of LPRC in the treatment of DIC. Method:Clinical effect of united transfusion of LPRC and FFP was compared with that of fresh whole blood transfusion, meanwhile the activities of t-PA in intraday whole blood, whole blood stored for 3 days and LPRC within 7 days were detected to get circumstantial evidence of the effect of LPRC in the treatment of DIC. Result:No statistic differences were found among the activities of t-PA in intraday whole blood, whole blood stored for 3 days and LPRC within 7 days. The same effect in rescuing DIC patients was achieved by using LPRC and FFP within 7 days instead of intraday fresh whole blood. Conclusion:No significant difference was found between the activities of t-PA in LPRC and FFP within 7 days and that of intraday fresh whole blood. Transfusion of fresh whole blood isn't necessarily emphasized in rescuing DIC patients. The same effect can be achieved if blood component is transfused in a reasonable way instead of fresh whole blood.