骨形态发生蛋白在多器官组织分化发育中的作用及研究进展

Roles of Bone Morphogenetic Proteins in the Differentiation and Development of Multiple Organs and Tissues

骨形态发生蛋白(Bone morphogenetic proteins,BMPs)是一种多功能蛋白,是转化生长因子TGF-β超家族成员,参与骨器官发生、形成与再生的过程,同时对神经系统、造血系统的分化发育也有调控作用.目前,BMPs的研究已经涉及发育生物学、遗传学等多个领域,并在临床上具有广泛的应用前景.基于相关研究近状,对BMPs的分子结构特征及其在多器官组织分化发育中的作用进行分析,为进一步研究BMPs的体内活性及临床应用提供了理论借鉴和参考.

Bone morphogenetic proteins(BMPs)are multi-functional proteins that belong to the transforming growth factor beta(TGF-β)superfamily.They involve in bone organogenesis,bone formation and regeneration,and regulate the differentiation and development of nervous system and hematopoietic system.To date,the studies on BMPs relate to many aspects such as development biology and genetics,and BMPs have great prospects for clinical use.A brief overview of the effect of BMPs on the differentiation and development of bone and other organs is provided.Further studies are needed on BMPs to refine our understanding of their activities in vivo and to optimize and expand their clinical use.