小剂量咪唑安定辅助硬膜外阻滞的临床观察

Clincal Obervation of Midazolam Sedation Following Epidural Block

目的持续小剂量咪唑安定辅助硬膜外阻滞的可行性和安全性。方法40例择期行全子宫切除术的患者,随机分成两组:观察组,20例,术中使用小剂量咪唑安定辅助镇压静;对照组,20例,术中使用氟芬合剂作为对照。记录给辅助药前(T0)、给药后2 min(T1)、5min(T2)、清醒(TW)时的脑电双频指数值,连续监测术中血流动力学及呼吸的情况。结果两组患者在镇静前后的BIS有显著性差异(P＜0．05);观察组的镇静、抗焦虑、消除内脏牵拉反应痛的的作用明显强于对照组(P＜0．05);两组的血流动力学及呼吸无明显影响,组间比较无统计学意义(P＞0．05)。结论持续小剂量咪唑安定能安全地辅助硬膜外阻滞,能更有效地增强镇静、抗焦虑、消除内脏牵拉痛等作用,而且对血流动力学和呼吸无影响。

Objective Clincal study of rnidazolam sedative action,anti-anxiety,decrease entrails pain,and the influence of naemodynamic and respiratory under epidural anesthesia.Methods:40 patients were divided randomly into two groups(N=20).GroupⅠwas injected midazolam 0.1mg/kg,then continous transfusion 0.03mg/kg.h by micropump. GroupⅡwas injected fentanyl lug/kg and droperidol 0.05ug/kg.Changes in BIS、MAP、HR、RR、SpO2 were recorded before and after inudtion.Results:BIS value were lower in groupⅠthan groupⅡafter induction.The groupⅠhave significant better sedaive action,anti-anxiety,decrease entrails pain than the groupⅡ(P＜0.05).Both two groups have no significant influence on haemodynamic and respiratory.Conclusions:Midazolam can increase sedative action,anti- anxiety,decrease entrail pain,have no significant influence on haemodynamic and respiratory under epidural anesthesia. It is can safety used in epidural anesthesia.