氢溴酸高乌甲素与吗啡硬膜外镇痛的临床比较

comparative study of postoperative patient_controlled epidural analgesia with Lappaconitine Hydrobromide Injection and morphine in patient undergoing ventral surgery

目的:比较术后患者氢溴酸高乌甲素(Ⅰ组)与吗啡(Ⅱ组)硬膜外自控镇痛(PCEA)的临床效果和不良反应。方法:60例ASAⅠ-Ⅱ级下愎部择期手术患者根据术后镇痛用药随机分为两组:氢溴酸高乌甲素(Ⅰ组,n=30)与吗啡(Ⅱ组,n=30)。术后连续监测BP、RR、ECG、SPO2。定时观察记录视觉模糊评分法(VSA)及恶心呕吐、嗜睡、多汗、皮肤瘙痒等不良反应。结果:两组术后4h、8h、16h、24h、32h、48h各时间VAS评分Ⅱ组略低于Ⅰ组,但差异无显著意义(P＞0．0 5)。恶心呕吐、嗜睡、多汗、皮肤瘙痒Ⅱ组明显高于Ⅰ组。结论:中下腹部手术后氢溴酸高乌甲素与吗啡硬膜外镇痛均有良好效果。但氢溴酸高乌甲紊不良反应少,值得推广。

Objective To compare the analgesic efficacy and side effects of patient-congtrolled epidural analgesia with Lappaconitine Hydrobromide Injection and morphine in patient undergoing ventral surgery.Methods 60 ASAⅠ-Ⅱpatients scheduled for ventral surgery were divided randomly into two groups:Lappaconitine Hydrobromide Injection PCEA group(Ⅰ)(n=30),morfhine PCEA group(Ⅱ)(n=30).BP、RR、ECG、SPO2 wre minitored continuously after operation.Efficacy of analgesia was assessed by VAS scores.Side effects such as drowsiness,sweat,nausea, vomiting,and skin pruritus were also observed.Results There was no significant difference in the mean VAS score between groupⅠandⅡat 4h,Sh,16h,24h,32h,48h,after operation.There was no significant difference in side effects between the group except the occurrence of drowsiness,sweat,nausea,vomiting,and skin pruritus which was lower in group Ithan in groupⅡ(P＜0.05)Conclusion PECA with Lappaconitine Hydrobromide Injection can provid satisfactory pain relief with fewer side effects compared with morphine PCEA.