紫杉醇为主的联合化疗方案治疗转移性乳腺癌

Clinical study of the treatment of metastatic breast cancer mainly by paclitaxol combined with chemotherapy

目的评价以紫杉醇为主的联合化疗方案治疗转移性乳腺癌的近期疗效和不良反应。方法紫杉醇150mg/m2静脉滴注第1天,根据以往化疗用药选择顺铂50mg/m2静脉滴注第2天至第3天,鬼臼乙叉甙60mg/m2静脉滴注,第1天至第3天,同时水化,利尿,或给予吡喃阿霉素40mg/m2第1天静脉注射。28d为一周期,治疗2~3周期后评价疗效。结果全组32例CR1例,PR18例,SD7例,PD6例,总有效率59.4%,初治有效率63.6%,复治有效率57.1%。紫杉醇联合表阿霉素方案有效率58.8%,紫杉醇联合顺铂方案有效率60.0%。主要不良反应为骨髓抑制,其次是消化道反应。结论以紫杉醇为主的联合化疗方案对转移性乳腺癌呈现较高疗效,对阿霉素耐药者及对铂类抗药的晚期乳腺癌也有很高的疗效。

OBJECTIVE To study the efficacy and toxicity of paclitaxol combined different chemotherapy in treatment of metastatic breast cancer.METHODS Paclitaxol 150mg/m^(2) iv drop on day 1;DDP 50mg/m^(2) iv drop for day 2 and 3;VP16 60mg/m^(2) iv drop for day 1 and 3;or EPI 40mg/m^(2) iv drop on day 1.each regimen 2 3 cycles and it was repeated every 28 days. RESULTS There are thirty-two patients.There are one complete respones and 18 partial response.The overall response rate was 59.4%.The response rate for 32 cases of novo patients was 63.6%,relapsed was 57.1%.Paclitaxol and EPI combined chemotherapy was 58.8%.Paclitaxol and DDP combined chemotherapy was 60.0%.The major side effects were myelsuppression,alopecia,nausea,vomiting,arthralgin and muscle pain.No severe sensitiviry reaction was observed.CONCLUSION The TP and TE combination chemotherapy is effective for metastatic breast cancer.