二次灭菌对热原不合格输液质量的影响

Effect of secondary sterilization on quality of three pyretogenic transfusions

目的考察二次灭菌对三种大输液热原等指标的影响情况。方法利用不同条件对三种大输液进行二次灭菌,比较了灭菌前后输液中内毒素的最大稀释倍数、pH、含量和5-HMF的变化。结果9g.L-1氯化钠注射液、100g.L-1葡萄糖注射液和50g.L-1葡萄糖注射液可分别选用四、三和三种二次灭菌条件。结论输液热原不合格时,可根据最大稀释倍数选用适宜的二次灭菌条件,进行第二次灭菌以减少损失。

OBJECTIVE To study the Effect of secondary sterilization on quality of pyretogenic transfusions.METHODS After three pyretogenic transfusions were sterilizated secondarily at different condition,the change in the MVD of endotoxin,pH and contents of NaCl,Glcose and 5-HMF were compared by method of pharmacopeia. RESULTS Four,two or four sterile conditions were selected respectively for 9g·L^(-1)Sodium Chloride Injection,100g·L^(-1)Glucose Injection and 50g·L^(-1)Glucose Injection.CONCLUSION It is suggested that this three pyretogenic transfusions might be asepticized secondarily at the suitable condition by the MVD for decreasing loss.