HER-2基因与乳腺癌综合治疗预后的关系
被引量：1
摘要
约 30 %的乳腺癌患者HER 2基因过表达 ,对化疗、内分泌治疗和放疗等产生抵抗 ,预后不良。越来越多的研究显示HER 2基因可作为乳腺癌综合治疗的独立预后因素 。
出处
《国际肿瘤学杂志》
CAS
2005年第1期38-41,共4页
Journal of International Oncology
参考文献20
-
1Kurebayashi J.Biological and clinical significance of HER2 overexpression in breast cancer. Breast Cancer . 2001
-
2Neve RM,Sutterluty H,Pullen N,et al.Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells. Oncegene . 2000
-
3Zhou BP,Hu MC,Miller SA,et al.HER-2/neu blocks tumor necrosis factor induced apoptosis via the Akt/NF-kappaB pathway. Journal of Biological Chemistry . 2000
-
4Konecny G,Pauletti G,Pegram M,et al.Quantitative association between HER-2/neu and steroid hormone receptors in hormone re-ceptor-positive primary breast cancer. Journal of the National Cancer Institute . 2003
-
5Witters L,Engle L,Lipton A.Restoration of estrogen responsiveness by blocking the HER-2/neu pathway. Oncology Reports . 2002
-
6Osborne CK,Schiff R.Growth factor receptor cross-talk with estrogen receptor as a mechanism for tamoxifen resistance in breast cancer. Breast Journal . 2003
-
7Xia F,Powell SN.The molecular basis of radiosensitivity and chemosensitivity in the treatment of breast cancer. Seminars in Radiation Oncology . 2002
-
8Kim R,Tanabe K,Uchida Y,et al.The role of HER-2 oncoprotein in drug-sensitivity in breast cancer. Oncology Reports . 2002
-
9Tanabe K,Kim R,Inoue H,et al.Antisense Bcl-2 and HER-2 oligonu-cleotide treatment of breast cancer cells enhances their sensitivity to an-ticancer drugs. International Journal of Oncology . 2003
-
10Jensen BV,Johansen JS,Price PA.High levels of serum HER-2/neu and YKL-40 independently reflect aggressiveness of metastatic breast cancer. Clinical Cancer Research . 2003
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-
1孙文欣,林晨,张叔人.HER-2/neu基因在肿瘤免疫治疗中的研究进展[J].国外医学（免疫学分册）,2005,28(1):13-16. 被引量：3
-
2俞平,杨兆瑞,路光中,胡宏慧,张俐雅.乳腺癌HER-2/neu的免疫组织化学检测[J].中华病理学杂志,2003,32(5):479-481. 被引量：10
-
3[3]Nabholtz JM,Reese DM,Lindsay MA,et al.HER2 -posi-tive breast cancer:,update on breast cancer international research group trials[J].Clin Breast Cancer,2002,3(suppl 2):S75-S79.
-
4[4]Gersler S,Lonning PE,Aas T,et al.Influence of TP53 gens alterations and HER-2 expression on the response to treatment with doxorubicin in locally advanced breast can-cer[J].Cancer Res,2001,61 (6):2505-2512.
-
5[7]Xu R,Feiner H,Li P,et al.Differential amplification and overexpression of HER-2 /neu,p53,MIB1,and estrogen receptor/progesterone receptor among medullary carcinoma,atypical medullary carcinoma,and high-grade invasive duetal carcinoma of breast[J].Arch Pathol Lab Med.2003,127(11):1458-1464.
-
6[8]Zhao J,Wu R,Au A,et al.Determination of HER2 gene amplification by chromogenie In situ hybridization (CISH) in archival breast carcinoma[J].Mod Pathol.2002,15(6):657-665.
-
7吴强,张瑰红,杨枫.乳腺癌及良性乳腺组织p185和p16蛋白表达的免疫组织化学研究[J].生物学杂志,2002,19(2):18-20. 被引量：5
-
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-
9张杰,舒维清,朱卫,何康林,王友珍,李小静.胃癌中Her-2/neu过表达与基因扩增及其意义[J].中华病理学杂志,2003,32(1):52-53. 被引量：17
-
10张世林,杨为民.HER-2原癌基因及其在膀胱癌中的研究进展[J].国外医学（泌尿系统分册）,2004,24(3):354-357. 被引量：3
-
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-
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-
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-
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-
5白连启,李世业,陈肖嘉,刘树库,龚昌帆,彭延生.474例小细胞肺癌的治疗分析[J].中华胸心血管外科杂志,1996,12(4):211-213. 被引量：15
-
6徐恩伟,王跃华,王晋芬.乳腺癌拓扑异构酶Ⅱα基因HER-2基因及Ki-67的关系研究[J].中国药物与临床,2012,12(11):1392-1394. 被引量：2
-
7张建立,马金海,崔伟,杨永滨.γ-tubulin、HER-2和k-ras在乳腺癌组织中的表达及临床意义[J].解放军医药杂志,2016,28(7):47-50. 被引量：2
-
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-
9袁步奇,杨安奎,陈伟超,欧阳电,郭朱明,张诠.老年舌癌患者153例临床特征及生存分析[J].中华肿瘤防治杂志,2010,17(19):1558-1561. 被引量：5
-
10冯志东,卢俊,吴泰璜.胰腺囊腺癌的诊断与治疗[J].山东医药,2008,48(24):39-40. 被引量：1
