摘要
Here we report the chemoenzymatic synthesis of Ro 25-8210 (1) and Ro 25-6630 (2) by using microbial reduction of a-chloromethyl ketone 4 mediated with baker’s yeast and Geotrichum sp. to afford the optically active (R) and (S)-α-chlorohydrin 8 respectively as the key step.
Here we report the chemoenzymatic synthesis of Ro 25-8210 (1) and Ro 25-6630 (2) by using microbial reduction of α-chloromethyl ketone 4 mediated with baker’s yeast andGeotrichum sp. to afford the optically active (R) and (S)-α-chlorohydrin 8 respectively as the key step.
