银屑病患者脑灌注的研究

Study on the Regional Cerebral Blood Flow in Psoriasis

目的了解银屑病患者局部脑血流的改变和有关影响因素。 方法采用单光子发射型计算机断层显像技术 ,通过半定量分析 ,对 2 3例银屑病患者及 1 1例健康对照者脑血流灌注进行观察和比较 ,同时以Zung’s焦虑自评量表 (SAS)及抑郁自评量表 (SDS)请患者自评 ,并对有关因素进行评估。 结果银屑病患者存在脑特定部位的异常低灌注 ,阳性率达 82 .6 1 % ,阳性部位依次为颞叶、枕叶、顶叶、额叶。焦虑、抑郁症状明显的患者 ,其脑局部血流低灌注更加明显。 结论银屑病患者存在脑局部血流障碍 ,其特定部位的低灌注与其情感障碍有关。

Objective In order to understand the regional cerebral blood flow(RCBF) in psoriasis and the related factors. Methods 23 patients with psoriasis were checked by single photon emission computed tomography(SPECT) through semiquantitative analysis. 11 matched normal controls were studied under identical conditions. All patients accepted the standardized personal interview, evaluation of a self-rating depression scale (SDS) and a self-rating anxiety scale of Zung's(SAS). Results Most of the patients with psoriasis had brain hypoperfusion in some areas. The incidence in psoriasis was 82.61% and abnormal areas in SPECT were the temporal lobe, occipital lobe, porietal lobe, and frontal lobe. The RCBF in psoriasis patients with symptoms of anxiety and depression was more significantly decreased. Conclusion Abnormal cerebral blood flow was identified in psoriasis. Hypoperfusion of the special areas was connected with mood disorders in psoriasis.