特比萘芬治疗皮肤孢子丝菌病

Terbinafine in treatment of cutaneous sporotrichosis

目的 :比较不同剂量特比萘芬片剂治疗皮肤孢子丝菌病的效果和安全性。方法 :6例皮肤孢子丝菌病病人分为A组和B组 ,对他们的临床表现、真菌学检查及组织病理学变化进行治疗前后的观察。A组 3例用特比萘芬 0 .2 5g ,po ,bid ,4wk后减量为 0 .12 5g ,bid直至痊愈。B组 3例用特比萘芬 0 .12 5g ,po ,bid直至痊愈。结果 :2组病人经过不同方式的治疗都获得临床、组织病理和真菌学痊愈。A组全疗程 12wk ,用药总量 2 8g。B组全疗程 2 0wk ,用药总量 35g。结论 :特比萘芬片治疗皮肤孢子丝菌病是安全有效的 ,其中A组更以其疗程短用药量少而值得推广。

AIM: To compare the efficiency and safety of domestic terbinafine tablet in treatment of cutaneous sporotrichosis. METHODS: Six patients with cutaneous sporotrichosis were randomly divided into two groups, A group and B group. Three patients of A group were given terbinafine 0.25 g, po , bid for 4 wk+0.125 g, po , bid until cure. B group were given 0.125 g, po , bid until cure. The clinical manifesifestation, mycology and histopathology of the patient before and after treatment were observed. RESULTS: Six patients reached clinical, mycological and histological total cure and no major adverse reactions were found. CONCLUSION: The domestic terbinaafine is effective and safe for the treatment of cutaneous sporotrichosis and propose clinical application.