乌拉地尔与酚妥拉明治疗重度肾实质性高血压的效果比较

The Efficacy of Introveneous Urapidil and Phentolamine in Patients with Severe renal Hypertension or Renal Hypertensive Emergency

目的 :比较乌拉地尔与酚妥拉明对重、急症肾实质性高血压的治疗效果。方法 :对 2 7例重、急症肾实质性高血压患者分别使用乌拉地尔和酚妥拉明进行治疗。观察用药后的临床表现 ,测定用药后 5、10、30、6 0、12 0min时的收缩压 (SBP)、舒张压 (DBP)、心率 (HR)。结果 :两治疗组在用药 5min、10min、30min、6 0min、12 0min各时点的SBP和DBP均明显低于治疗前。酚妥拉明组用药后 30min、6 0min时的SBP和DBP均明显低于乌拉地尔组 ,部分患者 (6 / 11)有体位性低血压表现 ,且HR明显更快。结论 :乌拉地尔在重、急症实质性高血压患者降压比酚妥拉明更为平稳 。

Object:To assess the efficacy of intravenous urapidil (U) and phentolamine (P) in patients with severe renal hypertension or renal hypertensive emergency.Methods:Twenty-seven patients with above diseases were divided into two treatment groups (U group and P group )randomly.The symptoms were observed and the SBP,DBP,and HR were measured at 5,10,30,60,120 min after treatment.Results:Compared with pretreatment,SBP and DBP at 5,10,30,60,120 min were reduced significantly in both groups.At 30 and 60 min,SBP and DBP in P group were lower significantly than in U group.About half of the patients in P group,however,showed positional hypotension and complained palpitation.Conclusion:Intravenous urapidil declines blood pressure more steady than phentolamine in treating severe renal hypertension or renal hypertensive emergecy.