血清β_(2)-微球蛋白测定对高血压早期肾损害的诊断价值

The Diagnostic Worth of Serum β_(2)-microglobulin Determination For early Nephricc Damage in Hypertensive

目的 :探讨血清 β2 -微球蛋白 (β2 -MG)测定对高血压早期肾损害的诊断价值。方法 :对 42例病程≤ 15年的高血压患者进行了血清 β2 -MG的检测。结果 :血清 β2 -MG在病程≤ 5年组及全部 42例患者中 ,其升高的阳性率高于血肌酐 (Cr) (P <0 .0 5 ,P <0 .0 2 5 ) ,且与血Cr呈正相关 (P <0 .0 5 ) ,在血清 β2 -MG升高组 ,视网膜动脉硬化的发生率高于血清 β2 -MG正常组 (P <0 .0 2 5 ) ,结论 :血清 β2 -MG在高血压早期就有变化 ,与血Cr相比 ,能更敏感地反映肾小球的功能 。

Object:To explore the worth of serum β 2 microglobulin (β 2 MG) determination in diagnosis of early nephric damage in hypertensive.Methods:Examine the levels of serum β 2 MG in 42 patients suffering froms hypertension for less than 15 years.Results:The positive rate of elevated serum β 2 MG was higher than that of elevated serum Creatinine (Cr) in both patients suffering from hypertension for less than 5 years ( P <0.05) and all 42 patients ( P <0.025),and had a positive relation with that of elevated serum Cr ( P <0.05).The occurring rate of retinal arteriosclerosis was higher in the group of elevated serum β 2-MG than in the group of normal serum β 2 MG level.Conclusions:Serum β 2 MG level can rise in early hypertension is more sensitive than serum Cr for determination of functional change of glomerule.Serum β 2 MG assay plays an important role in early diagnosis of renal arteriolosclerosis.