The cloning of 3'-truncated preS/S gene from HBV genomic DNA and its expression in transgenic mice 被引量：18

The cloning of 3'-truncated preS/S gene from HBV genomic DNA and its expression in transgenic mice

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摘要 INTRODUCTIONHepatitis B virus (HBV) is regarded as one of themain etiologic factors involved in the developmentof human hepatocellular carcinoma (HCC).The open reading frame (orf)of X gene of HBVencoded a transactivating factor is the evidence thatstrongly supported the notion that the X gene ofHBV DNA integrated in HCC genomic DNA couldcontribute to the carcinogenesis of liver cells byactivation of some related cellular genes

作者 Yi Ping Hu~1 Yu Cheng Yao~1 Jian Xiu Li~1 Xin Min Wang~1 Hong Li~2 Zhong Hua Wang~1 Zhang Heng Lei~3 1 Department of Cell Biology,Second Military Medical University,Shanghai 200433,China 2 Department of Biology,Department of Basic Medicine,West-China University of Medical Sciences,Chengdu 610041,China 3 Department of Biology,North Sichuan Medical College,Nanchong 637007,China

出处《World Journal of Gastroenterology》 SCIE CAS CSCD 2000年第5期734-737,共4页 世界胃肠病学杂志（英文版）

基金 Projects of the Science Development Foundation of Shanghai (994919033) Tackling Key Problems in Science and Technology from the State Science and Technology Ministry(TJ99LA01)

关键词 hepatitis B virus gene EXPRESSION mice TRANSGENE POLYMERASE chain reaction DNA recombinant HEPATOMA hepatitis B virus gene expression mice transgene polymerase chain reaction DNA recombinant hepatoma

分类号 R512.62 [医药卫生—内科学] R735.7 [医药卫生—肿瘤]

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