Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 expression in fibrotic rat liver 被引量：31

Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 expression in fibrotic rat liver

下载PDF

导出

摘要 INTRODUCTIONLiver fibrosis is an excessive deposition ofextracellular matrix(ECM)resulted from bothincreased synthesis and decreased degradation.Matrix metalloproteinases(MMPs)represent agroup of neutral proteinases with variable

作者 Liu HL Li XH Wang DY Yang SP

机构地区 Shanghai Med Univ

出处《World Journal of Gastroenterology》 SCIE CAS CSCD 2000年第6期881-884,共4页 世界胃肠病学杂志（英文版）

基金 Natural Science Foundation of Committee of Science and Technology of Shanghai Municipality(952B14003) Science and Technology Development Foundation of Educational Committee of Shanghai Municipality(96B06).

关键词 MATRIX METALLOPROTEINASE liver CIRRHOSIS POLYMERASE chain reaction EXTRACELLULAR MATRIX HEPATIC stellate cells rats matrix metalloproteinase liver cirrhosis polymerase chain reaction extracellular matrix hepatic stellate cells rats

分类号 R575.2 [医药卫生—消化系统]

引文网络
相关文献

参考文献42

1Kevin Michael Walsh,Peter Timms,Stewart Campbell,Ronald Norman,Maciver Macsween,Allan John Morris.Plasma Levels of Matrix Metalloproteinase-2 (MMP-2) and Tissue Inhibitors of Metalloproteinases-1 and -2 (TIMP-1 and TIMP-2) as Noninvasive Markers of Liver Disease in Chronic Hepatitis C Comparison Using ROC Analysis[J]. Digestive Diseases and Sciences . 1999 (3)
2Ralf Lichtinghagen,Karin Breitenstein,Burkhard Arndt,Tanja Kühbacher,K. H. W. B?ker.Comparison of matrix metalloproteinase expression in normal and cirrhotic human liver[J]. Virchows Archiv . 1998 (2)
3Walsh KM,Timms P,Campbell S,MacSween RN,Morris AJ.Plasma levels of matrix metalloproteinase-2 (MMP-2) and tissue inhibitors of metalloproteinases -1 and -2 (TIMP-1 and TIMP-2) as noninvasive markers of liver disease in chronic hepatitis C: comparison using ROC analysis. Digestive Diseases and Sciences . 1999
4Arthur MJ.Role of Ito cells in the degradation of matrix in liver. Journal of Gastroenterology . 1995
5Arthur MJP.Collagenases and liver fibrosis. Journal of Herpetology . 1995
6Arthur,MJ,Mann,DA,Iredale,JP.Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis. Journal of Gastroenterology . 1998
7Arthur MJ.Fibrogenesis Ⅱ.Metalloproteinases and their inhibitors in liver fibrosis. American Journal of Physiology Gastrointestinal and Liver Physiology . 2000
8Friedman SL.Cellular sources of collagen and regulation of collagen production in liver. Seminars in Liver Disease . 1990
9Levy,MT,Trojanowska,M,Reuben,A,Oncostatin,M.A cytokine upregulated in human cirrhosis, increases collagen production by human hepatic stellate cells. Journal of Hepatology . 2000
10Iredale JP,Benyon RC,Pickering J,McCullen M,Northrop M,Pawley S,Hovell C,Arthur MJ.Mechanisms of spontaneous resolution of rat liver fibrosis.Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. The Journal of Clinical Investigation . 1998

共引文献91

1王玉涵,展凡,程卉,郑凤,谢忠稳,李庆林.表儿茶素对四氯化碳诱导肝纤维化大鼠的干预作用[J].安徽中医药大学学报,2020,0(1):50-55. 被引量：8
2Xin Huang1,Ding Guo Li1,Zhi Rong Wang1,Hong Shan Wei1,Ji Lin Cheng1,Yu Tao Zhan1,Xin Zhou1,Qin Fang Xu1,Xin Li2,Han Ming Lu1 1Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China2Ninth Hospital. Shanghai Second Medical University, Shanghai 200011. China.Expression changes of activin A in the development of hepatic fibrosis[J].World Journal of Gastroenterology,2001,7(1):37-41. 被引量：12
3Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book..Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis[J].World Journal of Gastroenterology,2001,7(3):363-369. 被引量：73
4范跃祖,张景涛.金属蛋白酶-2及其组织抑制因子在原发性胆囊癌的表达及意义(英文)[J].外科研究与新技术,2004(2):144-151.
5张惠忠,吕志强,谢德荣,李海刚,熊利华,张华,陈晓兵.COX-2和MMP-2蛋白的表达对肺癌预后的影响[J].癌症,2004,23(10):1190-1193. 被引量：1
6范玉晶,韩明子.基质金属蛋白酶和消化道肿瘤的相关性[J].世界华人消化杂志,2004,12(9):2174-2176. 被引量：11
7Chuan-YongGuo,Jian-YeWu,Yun-BinWu,Min-ZhangZhong,Han-MingLu.Effects of endothelin-1 on hepatic stellate cell proliferation,collagen synthesis and secretion,intracellular free calcium concentration[J].World Journal of Gastroenterology,2004,10(18):2697-2700. 被引量：14
8Xiao-ZhongWang Sheng-JunZhang Yun-XinChen Zhi-XinChen Yue-HongHuang Li-JuanZhang.Effects of platelet-derived growth factor and interleukin-10 on Fas/Fas-ligand and Bcl-2/Bax mRNA expression in rat hepatic stellate cells in vitro[J].World Journal of Gastroenterology,2004,10(18):2706-2710. 被引量：35
9刘兰芳,杜新生,李燕,赵晓明,高继红.Cox-2、VEGF在乳腺癌中的研究进展[J].承德医学院学报,2005,22(1):65-68. 被引量：1
10Makoto Nakamuta,Kazuhiro Kotoh,Munechika Enjoji,Hajime Nawata.Effects of fibril- or fixed-collagen on matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 production in the human hepatocyte cell line HLE[J].World Journal of Gastroenterology,2005,11(15):2264-2268. 被引量：14

同被引文献279

1Wen Jie Dai,Hong Chi Jiang Second Department of General Surgery, the First Clinical School, Harbin Medical University, Harbin 150001, Heilongjiang Province, China.Advances in gene therapy of liver cirrhosis: a review[J].World Journal of Gastroenterology,2001,7(1):1-8. 被引量：34
2Hong Lei Weng,Wei Min Cai,Rong Hua Liu Institute of Infectious Diseases, First Affiliated Hospital. Medical School. Zhejiang University, Hangzhou 310003, Zhejiang Province. China.Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis[J].World Journal of Gastroenterology,2001,7(1):42-48. 被引量：53
3Ji Yao Wang,Qi Sheng Zhang,Ji Sheng Guo,Mei Yu Hu Department of Gastroenterology, Zhongshan Hospital, Medical Center, Fu Dan University Shanghai Medical University), Shanghai 200032, China.Effects of glycyrrhetinic acid on collagen metabolism of hepatic stellate cells at different stages of liver fibrosis in rats[J].World Journal of Gastroenterology,2001,7(1):115-119. 被引量：29
4Stephan vom Dahl,Gerald Kircheis,Dieter Haussinger.Hepatic encephalopathy as a complication of liver disease[J].World Journal of Gastroenterology,2001,7(2):152-156. 被引量：2
5Vasiliy I Reshetnyak,Tatyana I Sharafanova,Ludmila U Ilchenko,Elena V Golovanova,Gennadiy G Poroshenko.Peripheral blood lymphocytes DNA in patients with chronic liver diseases[J].World Journal of Gastroenterology,2001,7(2):235-237. 被引量：6
6Guo Liang Zhang Ye Hong Wang Hui Ling Teng Zhi Bin Lin Department of Pharmacology,School of Basic Medical Sciences,Beijing University,Beijiog 100083,ChinaDr.Guo Liang Zhang graduated from Xinxiang Medical College in 1982,got Ph.D.at Nagoya City University Medical School,Japan in 1994,finished postdoctoral research at Beijing Medical Univcrsity in 1996,now an associate professor of pharmacology,specialized in hepatic pharmacology,having 15 papers published..Effects of aminoguanidine on nitric oxide production induced by inflammatory cytokines and endotoxin in cultured rat hepatocytes[J].World Journal of Gastroenterology,2001,7(3):331-334. 被引量：20
7Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book..Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis[J].World Journal of Gastroenterology,2001,7(3):363-369. 被引量：73
8Lin Zhuang Jing You Bao Zhang Tang Su Ying Ding Kui Hua Yan Dan Peng Yan Mei Zhang Lu Zhang ~1Department of Hepatology,Kunming Third Municipal Peoples Hospital,Kunming 650041,Yunnan Province,China ~2Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China.Preliminary results of Thymosin-a1 versus interferon-α treatment in patients with HBeAg negative and serum HBV DNA positive chronic hepatitis B[J].World Journal of Gastroenterology,2001,7(3):407-410. 被引量：22
9Jing You Lin Zhuang Bao Zhang Tang Wei Bo Yang Su Ying Ding Wu Li Rong Xue Wu Hong Li Zhang Yan Mei Zhang Shao Ming Yan Lu Zhang ~1Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China ~2Departrnent of Hepatology,Kunming Third Municipal People’s Hospital,Kunming 650041,Yunnan Province,China.A randomized controlled clinical trial on the treatment of Thymosin-a1 versus interferon-α in patients with hepatitis B[J].World Journal of Gastroenterology,2001,7(3):411-414. 被引量：48
10Xiao-Hui Si Lian-Jun Yang Research Institute of Stomatology,the Ninth People’s Hospital,Shanghai Second Medical University,Shanghai 200011,ChinaDepartment of Pathology,Fourth Military Medical University,Xi’an 710033,Shaanxi Province,China.Extraction and purification of TGFβ and its effect on the induction of apoptosis of hepatocytes[J].World Journal of Gastroenterology,2001,7(4):527-531. 被引量：15

引证文献31

1王宇,贾继东.已酮可可碱的抗肝纤维作用及其机制[J].临床肝胆病杂志,2007,23(3):230-232. 被引量：1
2Li Hou Ying Li Yong-Hua Jia Bo Wang Yi Xin Mao-Ying Ling Shen Lü Department of Pathology,Dalian Medical University,Dalian 116027,Liaoning Province,ChinaDepartment of Biochemistry,Dalian Medical University,Dalian 116027,Liaoning Province,China.Molecular mechanism about lymphogenous metastasis of hepatocarcinoma cells in mice[J].World Journal of Gastroenterology,2001,7(4):532-536. 被引量：47
3Ping-Sheng Chen~(1,2) Wei-Rong Zhai~1 Xiao-Mei Zhou~3 Jin-Sheng Zhang~1 Yue-E Zhang~1 Yu-Qin Ling~1 Ying-Hong Gu~1 1 Department of Pathology,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China2 Ping-Sheng Chen now works in the Department of Pathology,School of Basic Medical Sciences the (former Nanjing Railway Medical College),Southeast University,Nanjing 210009,China3 Institute of Cancer Research,Shanghai 200032,China.Effects of hypoxia,hyperoxia on the regulation of expression and activity of matrix metalloproteinase-2 in hepatic stellate cells[J].World Journal of Gastroenterology,2001,7(5):647-651. 被引量：18
4范玉晶,韩明子.基质金属蛋白酶和消化道肿瘤的相关性[J].世界华人消化杂志,2004,12(9):2174-2176. 被引量：11
5Wei-DaZheng Li-JuanZhang Mei-NaShi Zhi-XinChen Yun-XinChen Yue-HongHuang Xiao-ZhongWang.Expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 in hepatic stellate cells during rat hepatic fibrosis and its intervention by IL-10[J].World Journal of Gastroenterology,2005,11(12):1753-1758. 被引量：34
6韩明子,范玉晶,王双双.基质金属蛋白酶-2,-9及铁蛋白对鉴别良恶性腹水的意义[J].世界华人消化杂志,2005,13(7):927-928. 被引量：5
7Yuan Jiang,Ze-Song Li,Fu-Sheng Jiang,Xin Deng,Cong-Shun Yao,Guang Nie.Effects of different ingredients of zedoary on gene expression of HSC-T6 cells[J].World Journal of Gastroenterology,2005,11(43):6780-6786. 被引量：5
8赵霞,姚希贤.白介素与肝纤维化[J].中国全科医学,2006,9(10):853-855. 被引量：11
9李玉莲,耿敬姝.不同组织微环境中人胃癌异种移植瘤生物学行为及明胶酶的表达差异[J].世界华人消化杂志,2006,14(32):3136-3138.
10高志刚,赵博,王振军,黄莚庭.端粒酶阴性和阳性肿瘤细胞侵袭能力的差异及机制研究[J].中华普通外科杂志,2007,22(5):382-385. 被引量：1

二级引证文献304

1曾维政,吴晓玲,蒋明德,陈晓斌,李明秀,熊碧君,徐辉.复方红景天抗肝纤维化作用的实验研究[J].中国中西医结合杂志,2003,23(S1):96-99. 被引量：2
2蒋凤莲,施为建,鞠文东,周巧云.骨髓转移瘤患者血清乳酸脱氢酶、D-二聚体检测的临床意义[J].实用癌症杂志,2014,29(2):137-139.
3孟燕妮,张桂英,李乾.氯沙坦对肝纤维化鼠TIMP-1,PAI-1表达的影响[J].世界华人消化杂志,2004,12(6):1361-1364. 被引量：5
4黄瑞健,孙培吾,张希,林乌拉,吴伟康.生长激素对大鼠心肌缺血再灌注后心肌细胞凋亡的作用[J].中国临床康复,2004,8(21):4212-4213.
5张生君,陈运新,陈治新,王小众.PDGF及白介素-10对大鼠肝星形细胞bcl-2/bax的影响[J].福建医科大学学报,2004,38(3):268-270. 被引量：1
6LiHou Jan-WuTang Xiao-NanCui BoWang BoSong LeiSun.Construction and selection of subtracted cDNA library of mouse hepatocarcinoma cell lines with different lymphatic metastasis potential[J].World Journal of Gastroenterology,2004,10(16):2318-2322. 被引量：9
7颜吉丽,范钰,李华,张锦生,黄富春.白介素-10对大鼠肝星状细胞核因子-κB、细胞因子及细胞间黏附分子-1表达的影响[J].世界华人消化杂志,2004,12(8):1947-1949.
8余小虎,朱金水,朱祖明,俞华芳,朱励,沈波.氧化苦参碱抗肝纤维化作用的病理学研究[J].胃肠病学和肝病学杂志,2004,13(5):485-487. 被引量：5
9谢汝佳,杨勤,罗新华,耿晓霞,韩冰,李诚秀,程明亮.丹芍化纤胶囊对基质金属蛋白酶-1表达的影响[J].贵阳医学院学报,2004,29(5):395-399. 被引量：4
10叶卉,陈志南,米力,商澎,骞爱荣,蒋建利,汪莉,谢丽,张敏.HAb18Gedomab1单抗的制备及功能研究[J].世界华人消化杂志,2004,12(9):2061-2065. 被引量：1

1谭勤锐,李晖,杨超.转化生长因子-β_1调控与肝纤维化治疗的研究进展[J].广东医学,2015,36(13):2109-2111. 被引量：2
2LIU Cheng 1, LIU Ping 1, LIU Cheng Hai 1, ZHU Xiu Qing 1 and JI Guang 1.Effects of Fuzhenghuayu decoction on collagen synthesis of cultured hepatic stellate cells,hepatocytes and fibroblasts in rats[J].World Journal of Gastroenterology,1998,4(6):93-94. 被引量：11
3蔡旭俊,卢君.小剂量阿奇霉素对支气管哮喘患儿肺功能及血清基质金属蛋白酶-9的影响[J].中国实用医刊,2014,41(12):23-25. 被引量：2
4Liver and Biliary System[J].China Medical Abstracts(Internal Medicine),2012,29(2):107-110.
5Wang LT,Zhang B,Chen JJ.Effect of anti-fibrosis compound on collagen expression of hepatic cells in experimental liver fibrosis of rats[J].World Journal of Gastroenterology,2000,6(6):877-880. 被引量：31
6Effects of taurine on proliferation and apoptosis of hepatic stellate cells in vitro[J].Hepatobiliary & Pancreatic Diseases International,2004,3(1):106-109. 被引量：1
7王小众.肝纤维化的发病机制及抗纤维化研究进展[J].中西医结合肝病杂志,2001,11(S1):35-38. 被引量：3
8刘春丽,商玮,赵凌杰,姚茹冰,董晓蕾,沈思钰,郭郡浩,赵智明,蔡辉.吡格列酮对高脂血症大鼠主动脉组织MMP-2、MMP-9表达的影响[J].河北医药,2014,36(5):659-662. 被引量：1
9A new immortalized rat cell line, hepatic stellate cell-PQ, exhibiting characteristics of hepatic stellate cell[J].Hepatobiliary & Pancreatic Diseases International,2005,4(2):281-284. 被引量：3
10Catherine H. Wu,Ph. D.(Department of Medicine,Division of Gastroenterology-Hepatology, University of Connec ticut Health Center, 263 Farmington Avenue, Farmington, Connecticut06030, USA).Fibrodynamics-elucidation of the mechanisms and sites of liver fibrogenesis[J].World Journal of Gastroenterology,1999,5(5):388-390. 被引量：15

World Journal of Gastroenterology

2000年第6期

浏览历史

内容加载中请稍等...