Polymorphism of p16INK4a gene and rare mutation of p15INK4b gene exon2 in primary hepatocarcinoma
被引量:30
Polymorphism of p161NK4a gene and rare mutation of p151NK4b gene exon2 in primary hepatocarcinoma
摘要
INTRODUCTION Hepatocellular carcinoma(HCC)is the mostcommon cause of death from cancer in China.Themechanisms of hepatocarcinogenesis are not yetknown clearly,p16INK4a gene,the multiple tumorsuppressor gene 1(MTS1),encodes P16 protein,which acts as an inhibitor by binding directly toCDK4 and CDK6 and preventing its association
作者
Yang Qin Bo Li Yong Shu Tan Zhi Lin Sun Feng Qiong Zuo Ze Fang Sun Institute of Biochemistry and Molecular Biology,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of General Surgery,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of Pathology,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China
基金
the National Natural Science Foundation of China,No.39670702
参考文献17
-
1Yoshida S,Todoroki T,Ichikawa Y,Hanai S,Suzuki H,Hori M,Fukao K,Miwa M,Uchida K.Ink4</sup> /CDKN2,p<sup>15Ink4B</sup>/MTS2 genes in biliary tract cancers&sid=Cancer Research&aufirst=Yoshida S');
 ">Mutations of p16<sup>Ink4</sup> /CDKN2,p<sup>15Ink4B</sup>/MTS2 genes in biliary tract cancers. Cancer Research . 1995
-
2Orlow I,Lacombe L,Hannon GJ,Serrano M,Pellicer I,Dalbagni G,Reuter VE,Zhang ZF,Beach D,Cordon-Cardo C.Deletion of the p16 and p15 genes in human bladder tumors. Journal of the National Cancer Institute . 1995
-
3Rusin MR,Okamoto A,Chorazy M,Czyzewski K,Harasim J,Spillare EA,Hagiwara K,Hussain SP,Xiong Y,Demetrick DJ,Harris CC.INK4</sup> ,p15<sup>INK4B</sup>and p18 genes in primary non-small-cell lung cancers&sid=International Journal of Cancer&aufirst=Rusin MR');
 ">Intragenic mutations of the p16<sup>INK4</sup> ,p15<sup>INK4B</sup>and p18 genes in primary non-small-cell lung cancers. International Journal of Cancer . 1996
-
4Kamb A.A cell cycle regulator potentially involved in genesis of many tumor types. Science . 1994
-
5Hannon,GJ,Beach,D.p15INK4b is a potential affector of TGF-beta-induced cell cycle arrest. Nature . 1994
-
6Nobori T,Miura K,Wu D J,Lois A,Takabayashi K,Carson D A.Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature . 1994
-
7Wu MS,Shun CT,Sheu JC,Wang HP,Wang JT,Lee WJ,Chen CJ,Wang TH,Lin JT.Overexpression of mutant p53 and c-erbB-2 proteins and mutations of the p15 and p16 genes in human gastric carcinoma: with respect to histological subtypes and stages. Journal of Gastroenterology . 1998
-
8Chaubert P,Gayer R,Zimmermann A,Fontolliet C,Stamm B,Bosman F,and Shaw P.Germ-line mutations of the pl6INK4 (MTS1) gene occur in a subset of patients with hepatocellular carcinoma. Hepatology . 1997
-
9Okamoto,A,Hussain,SP,Hagiwara,K,Spillare,EA,Rusin,MR,Demetrick,DJ,Serrano,M,Hannon,GJ,Shiseki,M,Zariwala,M,Xiong,Y,Beach,DH,Yokota,J,Harris,CC.Mutations in the p16ink4/MTS1/CDKN2, p15ink4B/MTS2, and p18 genes in priamry and metastatic lung cancer. Cancer Research . 1995
-
10H. Sill</span>, R. C. T. Aguiar</span>, H. Schmidt</span>, A. Hochhaus</span>, J. M. Goldman</span> &,N. C. P. Cross</span>.Mutational analysis of the p15 and p16 genes in acute leukaemias. British Journal of Haematology . 1996
同被引文献259
-
1XI CHEN,WEI ZHANG,YUN FEI GAO,XIAO QIN SU,ZHONG HE ZHAI.Senescence-like changes induced by expression of p21^(Waf1/Cip1) in NIH3T3 cell line[J].Cell Research,2002,12(4):229-233. 被引量:9
-
2Yu Cheng Tang,Yu Li,Guan Xiang Qian Department of Biochemistry, Shanghai Second Medical University, Shanghai 200025, China.Reduction of tumorigenicity of SMMC-7721 hepatoma cells by vascular endothelial growth factor antisense gene therapy[J].World Journal of Gastroenterology,2001,7(1):22-27. 被引量:33
-
3Jia Fan,Zhi Quan Wu,Zhao You Tang,Jian Zhou,Shuang Jian Qiu,Zeng Chen Ma,Xin Da Zhou,Sheng Long Ye Liver Cancer Institute, Zhongshan Hospital, Fudan University Medical Center (Former Shanghai University), 136 Yixueyuan Road, Shanghai 200032, China.Multimodality treatment in hepatocellular carcinoma patients with tumor thrombi in portal vein[J].World Journal of Gastroenterology,2001,7(1):28-32. 被引量:80
-
4De Yun Feng,Hui Zheng,Yi Tan,Rui Xue Cheng Department of Pathology, Hunan Medical University, Changsha 410078, Hunan Province, China New England Biolab, MA, USA.Effect of phosphorylation of MAPK and Stat3 and expression of c-fos and c-jun proteins on hepatocarcinogenesis and their clinical significance[J].World Journal of Gastroenterology,2001,7(1):33-36. 被引量:75
-
5Jing Xu1,Ming Hui Mei1,Si En Zeng2,Qing Fen Shi3,Yong Ming Liu4,Li Ling Qin3 1Department of Hepatobiliary Surgery2Department of Pathology3Institute of Hepatobiliary Surgery4Department of Biochemistry, Guilin 541001, Guangxi Province, China.Expressions of ICAM-1 and its mRNA in sera and tissues of patients with hepatocellular carcinoma[J].World Journal of Gastroenterology,2001,7(1):120-125. 被引量:14
-
6Li Hua Liu1,Wen Hua Xiao2,Wei Wen Liu3 1Department of Oncology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China (now working in Department of Gastroenterology, General Hospital of PLA, Lanzhou 730050, Gansu Province, China)2Department of Oncology3Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.Effect of 5-Aza-2'-deoxycytidine on the P16 tumor suppressor gene in hepatocellular carcinoma cell line HepG2[J].World Journal of Gastroenterology,2001,7(1):131-135. 被引量:21
-
7Jun Cui,Dong Hua Yang,Xiang Jun Bi,Zi Rong Fan Department of Gastroenterology, Zhujiang Hospital, The First Military Medical University, Guangzhou 510282, Guangdong Province, China.Methylation status of c-fms oncogene in HCC and its relationship with clinical pathology[J].World Journal of Gastroenterology,2001,7(1):136-139. 被引量:16
-
8Christian Rabe,Tillmann Pilz,Christoph Klostermann,Marc Berna,Hans H.Schild,Tilman Sauerbruch,Wolfgang H.Caselmann.Clinical characteristics and outcome of a cohort of 101 patients with hepatocellular carcinoma[J].World Journal of Gastroenterology,2001,7(2):208-215. 被引量:60
-
9Lian Jun Yang,Yan Fang Sui,Zhi Nan Chen Department of Pathology, Fourth Military Medical University. Xi’an 710032, Shaanxi Province, China.Preparation and activity of conjugate of monoclonal antibody HAb18 against hepatoma F( ab′ )_2 fragment and staphylococcal enterotoxin A[J].World Journal of Gastroenterology,2001,7(2):216-221. 被引量:20
-
10Wei Xin Niu,Xin Yu Qin,Han Liu,Cheng Pei Wang Surgical Department, Zhongshan Hospital, Fu Dan University Medical Center, Shanghai 200032, China.Clinicopathological analysis of patients with gastric cancer in 1200 cases[J].World Journal of Gastroenterology,2001,7(2):281-284. 被引量:29
引证文献30
-
1Li Hua Liu1,Wen Hua Xiao2,Wei Wen Liu3 1Department of Oncology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China (now working in Department of Gastroenterology, General Hospital of PLA, Lanzhou 730050, Gansu Province, China)2Department of Oncology3Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.Effect of 5-Aza-2'-deoxycytidine on the P16 tumor suppressor gene in hepatocellular carcinoma cell line HepG2[J].World Journal of Gastroenterology,2001,7(1):131-135. 被引量:21
-
2Jun Cui,Dong Hua Yang,Xiang Jun Bi,Zi Rong Fan Department of Gastroenterology, Zhujiang Hospital, The First Military Medical University, Guangzhou 510282, Guangdong Province, China.Methylation status of c-fms oncogene in HCC and its relationship with clinical pathology[J].World Journal of Gastroenterology,2001,7(1):136-139. 被引量:16
-
3Xiu-Sheng He Qi Su Zhu-Chu Chen Xiu-Tao He Zhi-Feng Long Hui Ling Liang-Run Zhang Oncology Institute,Nanhua University,Hengyang 421001,Hunan Province,ChinaOncology Institute,Center South University,Changsha 410078,Hunan Province,China Department of Gastroenterology,First People’s Hospital of Changde City,Changde 415003,Hunan Province,China.Expression,deleton and mnutation of ρ16 gene in human gastric cancer[J].World Journal of Gastroenterology,2001,7(4):515-521. 被引量:40
-
4Zheng-Xu Wang~1 Gui-Fang Hu~1 Hong-Yang Wang~2 Meng-Chao Wu~2 1 Department of General Surgery,Chinese PEA General Hospital of Lanzhou Military Command,Lanzhou 730050,Gansu Province,China2 Eastern Hepatobilliary Surgical Hospital,Second Military Medical University,Shanghai 200438,China.Expression of liver cancer associated gene HCCA3[J].World Journal of Gastroenterology,2001,7(6):821-825. 被引量:9
-
5张昕博,刘彦群,魏志平.p16基因及其与皮肤鳞癌相关性的研究进展[J].徐州医学院学报,2005,25(1):89-91.
-
6魏志平,刘彦群,张昕博.皮肤鳞状细胞癌中p16蛋白、细胞周期蛋白D1的表达及其意义[J].临床皮肤科杂志,2005,34(5):291-292. 被引量:2
-
7刘彦群,魏志平,张昕博.p16和pRb在皮肤鳞癌中的表达及其意义[J].中国麻风皮肤病杂志,2005,21(8):595-597. 被引量:2
-
8董科,李波,覃杨,刘建余,李承志,孙芝琳.胰腺组织p15、p16抑癌基因CpG岛甲基化研究(英文)[J].The Chinese-German Journal of Clinical Oncology,2005,4(4):213-217. 被引量:3
-
9贾新颜,王健民,李扬秋,陈少华,章卫平,陈莉.异基因造血干细胞移植患者外周血TCR Vβ亚家族克隆性增殖动态变化及其与GVHD的关系[J].中国实验血液学杂志,2007,15(4):795-800. 被引量:1
-
10石晶,周之海.β-连接蛋白和细胞周期蛋白D1在乳房外Paget病中的表达[J].天津医科大学学报,2009,15(2):240-242. 被引量:2
二级引证文献395
-
1李玲,马华玲,张文娟.激光共聚焦显微镜在肿瘤研究方面的应用[J].医学信息(医学与计算机应用),2014,0(34):390-390. 被引量:1
-
2党伟,张娣,果应菲,赵晓东,孙荣距.CDKN2/p16基因HapⅡ位点甲基化与肺癌关系的研究[J].感染.炎症.修复,2008,9(4):210-212. 被引量:2
-
3罗春华,朱建思,苏影,周建国,董琳.外源性p16基因对人原发性肝癌细胞生物学行为的影响及其机制[J].湖南师范大学学报(医学版),2005,2(1):24-29. 被引量:1
-
4Maija H Zile.Abnormal β-catenin gene expression with invasiveness of primary hepatocellular carcinoma in China[J].World Journal of Gastroenterology,2001,7(4):542-546. 被引量:22
-
5Zheng-Xu Wang~1 Gui-Fang Hu~1 Hong-Yang Wang~2 Meng-Chao Wu~2 1 Department of General Surgery,Chinese PEA General Hospital of Lanzhou Military Command,Lanzhou 730050,Gansu Province,China2 Eastern Hepatobilliary Surgical Hospital,Second Military Medical University,Shanghai 200438,China.Expression of liver cancer associated gene HCCA3[J].World Journal of Gastroenterology,2001,7(6):821-825. 被引量:9
-
6Xi Peng Jin-Bin Feng Hong Yan Yun Zhao Shi-Liang Wang Institute of Burn Research,Southwest Hospital,Third Military Medical University,Chongqing 400038,China.Distribution of nitric oxide synthase in stomach myenteric plexus of rats[J].World Journal of Gastroenterology,2001,7(6):852-854. 被引量:11
-
7Hong-Chi Jiang~1 Bei Sun~1 Hai-Quan Qiao~1 Jun Xu~1 Da-Xun Piao~1 Hang Yin~2 1 Department of General Surgery,First Clinical Hospital,Harbin Medical University,Harbin 150001,China2 Department of General Surgery,Heilongjiang Provincial Hospital,Harbin 150001,China.Clinical application of serial operations with preserving spleen[J].World Journal of Gastroenterology,2001,7(6):876-879. 被引量:8
-
8刘小方,于绍平,张翠生,王在秋,苏海龙,周先亭.5-氮-2-脱氧胞苷调控胆管癌p53-Bax线粒体凋亡通路DNA甲基化诱导化疗敏感性的研究[J].中华临床医师杂志(电子版),2011,5(21):6266-6272. 被引量:4
-
9Regina Cheuk-Lam Lo,Irene Oi-Lin Ng.Hepatocellular Tumors:Immunohistochemical Analyses for Classification and Prognostication[J].Chinese Journal of Cancer Research,2011,23(4):245-253. 被引量:5
-
10Deng-Fu Yao,Xin-Hua Wu,Xiao-Qin Su,Min Yao, Wei Wu, Li-Wei Qiu, Li Zou and Xian-Yong Meng The Institute of Clinical Medicine, Nantong University, and Department of Gastroenterology,Affiliated Hospital of Nantong University, Nantong 226001, China,and Nanjing Medical University, Nanjing 210009, China.Abnormal expression of HSP gp96 associated with HBV replication in human hepatocellular carcinoma[J].Hepatobiliary & Pancreatic Diseases International,2006,5(3):381-386. 被引量:14
-
1徐继,何琦文,何徐军,邵钦树,陶厚权,叶再元.NEK-在胃癌中的表达及临床意义[J].中华胃肠外科杂志,2015,18(10):1036-1040. 被引量:2
-
2李龙萍,匡小燕,邓飞.非霍奇金淋巴瘤中p16基因突变与MSI的关系[J].遵义医学院学报,2013,36(5):417-421.
-
3徐晓峰,周四维,张征宇,葛京平,程文,位志峰,张旭,高建平.Malignant Phenotype of PC3 Cell Line Was Inhibited by siRNA Targeting PAR Gene[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2007,27(4):440-443. 被引量:2
-
4黄红彦,崔永华,唐大椿,陶雁玲,刘秋润.p16基因突变与喉癌生物学行为的相关性[J].临床耳鼻咽喉科杂志,2001,15(6):253-254. 被引量:3
-
5QinxianZhang RuoFeng WeiZhang XueyiShi.Role of stress-activated P38 MAP kinase in cisplatin and DTT induced apoptosis of the esophageal carcinoma cell Line eca109[J].中国组织化学与细胞化学杂志,2004,13(3):350-350.
-
6XiaoliZhang AihuaBo LinaJiang.Expression and significance of p16 protein in esophageal squamous cell carcinoma[J].中国组织化学与细胞化学杂志,2004,13(3):347-348.
-
7曹跃琼,王丰,乔守怡.PCR-SSCP研究肝癌原发灶和转移灶中P16^(INK4)exon2的突变[J].复旦学报(自然科学版),1998,37(4):537-541.
-
8王旭亮,李彩灵,杨丽华,江智茂,桂耀庭,蔡志明.UTX在肾癌中的高表达及其临床意义[J].北京大学学报(医学版),2014,46(6):926-930. 被引量:1
-
9黄毓,甘登仕,薜小霞.急性淋巴细胞白血病P^(16)基因纯合子缺失的研究[J].广西医科大学学报,2000,17(1):26-27.
-
10GUO Xian Ke 1, WANG Ti Jun 2 and GU Jing Fan 3 Keywords esophageal neoplasms,stomach neoplasms,vinegar,N nitrosoproline,gas chromatography.Effect of esophagus and stomach cancer-preventing vinegar on N-nitrosoproline formation in human body[J].World Journal of Gastroenterology,1997,3(4):71-72. 被引量:1