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Polymorphism of p16INK4a gene and rare mutation of p15INK4b gene exon2 in primary hepatocarcinoma 被引量：30

Polymorphism of p161NK4a gene and rare mutation of p151NK4b gene exon2 in primary hepatocarcinoma
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摘要 INTRODUCTION Hepatocellular carcinoma(HCC)is the mostcommon cause of death from cancer in China.Themechanisms of hepatocarcinogenesis are not yetknown clearly,p16INK4a gene,the multiple tumorsuppressor gene 1(MTS1),encodes P16 protein,which acts as an inhibitor by binding directly toCDK4 and CDK6 and preventing its association
作者 Yang Qin Bo Li Yong Shu Tan Zhi Lin Sun Feng Qiong Zuo Ze Fang Sun Institute of Biochemistry and Molecular Biology,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of General Surgery,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of Pathology,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2000年第3期411-414,共4页 世界胃肠病学杂志（英文版）
基金 the National Natural Science Foundation of China,No.39670702
关键词 P16INK4A GENE P15INK4B GENE POLYMORPHISM MUTATION HEPATOCARCINOMA p16INK4a gene p15INK4b gene polymorphism mutation hepatocarcinoma
分类号 R735.7 [医药卫生—肿瘤]
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参考文献17

  • 1Yoshida S,Todoroki T,Ichikawa Y,Hanai S,Suzuki H,Hori M,Fukao K,Miwa M,Uchida K.Ink4</sup> /CDKN2,p<sup>15Ink4B</sup>/MTS2 genes in biliary tract cancers&amp;sid=Cancer Research&amp;aufirst=Yoshida S');&#xA; ">Mutations of p16<sup>Ink4</sup> /CDKN2,p<sup>15Ink4B</sup>/MTS2 genes in biliary tract cancers. Cancer Research . 1995
  • 2Orlow I,Lacombe L,Hannon GJ,Serrano M,Pellicer I,Dalbagni G,Reuter VE,Zhang ZF,Beach D,Cordon-Cardo C.Deletion of the p16 and p15 genes in human bladder tumors. Journal of the National Cancer Institute . 1995
  • 3Rusin MR,Okamoto A,Chorazy M,Czyzewski K,Harasim J,Spillare EA,Hagiwara K,Hussain SP,Xiong Y,Demetrick DJ,Harris CC.INK4</sup> ,p15<sup>INK4B</sup>and p18 genes in primary non-small-cell lung cancers&amp;sid=International Journal of Cancer&amp;aufirst=Rusin MR');&#xA; ">Intragenic mutations of the p16<sup>INK4</sup> ,p15<sup>INK4B</sup>and p18 genes in primary non-small-cell lung cancers. International Journal of Cancer . 1996
  • 4Kamb A.A cell cycle regulator potentially involved in genesis of many tumor types. Science . 1994
  • 5Hannon,GJ,Beach,D.p15INK4b is a potential affector of TGF-beta-induced cell cycle arrest. Nature . 1994
  • 6Nobori T,Miura K,Wu D J,Lois A,Takabayashi K,Carson D A.Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature . 1994
  • 7Wu MS,Shun CT,Sheu JC,Wang HP,Wang JT,Lee WJ,Chen CJ,Wang TH,Lin JT.Overexpression of mutant p53 and c-erbB-2 proteins and mutations of the p15 and p16 genes in human gastric carcinoma: with respect to histological subtypes and stages. Journal of Gastroenterology . 1998
  • 8Chaubert P,Gayer R,Zimmermann A,Fontolliet C,Stamm B,Bosman F,and Shaw P.Germ-line mutations of the pl6INK4 (MTS1) gene occur in a subset of patients with hepatocellular carcinoma. Hepatology . 1997
  • 9Okamoto,A,Hussain,SP,Hagiwara,K,Spillare,EA,Rusin,MR,Demetrick,DJ,Serrano,M,Hannon,GJ,Shiseki,M,Zariwala,M,Xiong,Y,Beach,DH,Yokota,J,Harris,CC.Mutations in the p16ink4/MTS1/CDKN2, p15ink4B/MTS2, and p18 genes in priamry and metastatic lung cancer. Cancer Research . 1995
  • 10H. Sill&lt;/span&gt;, R. C. T. Aguiar&lt;/span&gt;, H. Schmidt&lt;/span&gt;, A. Hochhaus&lt;/span&gt;, J. M. Goldman&lt;/span&gt; &amp,N. C. P. Cross&lt;/span&gt;.Mutational analysis of the p15 and p16 genes in acute leukaemias. British Journal of Haematology . 1996

同被引文献259

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World Journal of Gastroenterology
2000年 第3期

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