航海人员中高血压患者血浆肾上腺髓质素(13～52)水平的变化

The Change or Adrenomedullin (13～52 ) in Nautical Personnel of Patients with Essential Hypertension

目的:观察我国航海人员中原发性高血压(EH)患者血浆肾上腺髓质素〔ADM(13～52)〕浓度变化,探讨其在EH患者发病中的病理生理意义.方法:用特异性放免法测定血浆ADM(13～52)含量.结果:39例航海人员中EH患者血浆ADM(13～52)水平〔(30.67±1.3)ng/L〕明显高于30例健康航海人员〔(18.98±1.l)ng/L,P<0.01〕;随着高血压病期的加重而增加(P<0.01),血浆ADM(13～52)水平与脉压差和血浆内皮素(ET-1)水平均呈正相关(r分别为0.553、0.567,P均<0.01).结论:ADM(13～52)是一种舒血管肽,EH患者血浆ADM(13～52)分泌释放增加是机体维持内环境稳态的一种代偿性保护机制.

Objective: To observe the pathophysio-logical significance of plasma adrenomedullin CADM (13-52)D changes of thirty-nine patients with essential hypertension in nautical personnel. Methods: The concentration of ADM(13-52) was measureed with special radioimmunoassay. Results; The plasma ADM (13-52) levels in nautical personnel of patients with essential hypertension [(30. 67?. 3) ng/L] were sig-nificantly higher than those in normal nautical personnel [(18. 98?. 1) ng/L,P<0. 01] and was well in-creased with the clinical stages or severity of the disease (P<0. 01), there was significantly positive correla-[ tion between the plasma ADM(13-52) level and pulse pressure, endothelin(ET) level. (r=0. 553,0. 567,P <0. 01). Conclusion; The ADM(13-52) is a kind of dilative peptide, the elevation of plasma ADM(13-52) in patients with EH may be part of the compensatory mechanism to meantain the body stabilly.