乙型肝炎病毒携带儿童血清病毒含量与母婴传播

Relationship between Virus Contents in Sera of Children and Vertical Transmission of HB

目的 探讨乙型肝炎病毒(HBV)携带儿童较高的血清病毒含量与母婴传播的关系。方法 调查214例人群抽查发现并经随访确证的HBsAg慢性携带儿童,并对所有研究对象及其母亲采血,ELISA试剂盒检测HBV感染的血清学标志物及表面抗原滴度。结果 母亲HBsAg阳性的HBV慢性携带儿童具有相对较高的HBsAg滴度及HBeAg阳性率;其年阴转率为0.4％,明显低于母亲HBsAg阴性的HBV慢性携带儿童年阴转率1.7％;发生母婴传播的孕妇HBsAg年阴转率为0.3％,显著低于同龄携带者人群HBsAg的自然阴转率。结论 HBV慢性携带儿童较高血清病毒含量可能与母婴传播有关,代代相传可能是我国母婴传播发生率较高进而形成我国巨大HBsAg携带者库的重要原因。

Objective To investigate the relationship of the virus content in the sera of children HBsAg chronic carrier and vertical transmission.Methods 214 HBsAg chronic carrier children identified by population- based sampling were investigated and all the subjects and their mothers were bleed; HBV sero- markers and HBsAg liters were detected with ELISA kits.Results In comparison witll those whose mothers were HBsAg negative carrier cluldren with HBsAg positive mothers had higher HBsAg liters and HBeAg positive rate, but lower annual sero - conversion rate of HBsAg (0.4% vs 1.7%), and their mothers' annual sero - conversion rate of HBsAg was 0.3% . Conclusions High HBV level may play a major role in maternal - infant transmission and high HBsAg positive rate in China.