膀胱癌术后射频热化疗对机体T淋巴细胞亚群的影响

Influence of the radiofrequency thermochemotherapy on T lymphocyte subgroup after bladder cancer resection

目的 探讨术后热化疗对膀胱癌患者T淋巴细胞亚群分布的影响。方法:58例膀胱移行细胞癌术后患者被随机分为热化疗组和化疗组。热化疗组30例,于术后1周行膀胱腔内射频热化疗。化疗组28例,术后1周行膀胱腔内灌注化疗。分别于治疗前及治疗后2周检测两组患者外周血T淋巴细胞亚群分布。30例健康体检者做为正常对照。结果:治疗前,两组患者CD_3^+、CD_4^+淋巴细胞百分数明显低于对照组,CD_8^+T淋巴细胞百分数明显升高。热化疗后CD_3^+、CD_4^+T淋巴细胞百分数升高,与对照组比较无明显差别,CD_8^+T淋巴细胞百分数下降。单纯化疗后T淋巴细胞亚群分布异常无明显改变。结论 射频热化疗对膀胱癌患者T淋巴细胞亚群分布异常有明显的改善作用。

Aim: To investigate the effects of radiofrequency thermochemotherapy(TCT) on T lymphocyte subgroup after bladder cancer resection. Methods: 58 cases of transitional bladder cancer were randomly assigned to receive thermo-chemotheropy (group A) ,and chem otherapy along (group B) . After one week of surgery,30 cases of group A received intravesical TCT;28 cases of group B received intravesical instillation chemotherapy . T lymphocyte subgroup with direct erythrocyte rosette test were measured before management and two weeks after that. 30 normal abults were as controls (group C) .Results: The percentage of CD+3, CD+4 T cells was obviously decreased before management ingroup A and group B than that in group C while it was obviously increased after two weeks of management in group A compare with group B It was no significantly difference in group B before and after management.Conclusion: TCT has a benefit effect on improving the disadjust of the percentage of T lymphocyte subgroup.