天棘软胶囊对高脂血症大鼠血脂、体内抗氧化系统和血管内皮系统的保护作用研究

Study on Protective Effect of Tianji Soft Capsule on Blood Lipids,Internal Antioxidant System and Vascular Endothelial System in Hyperlipidemia Rats

目的研究天棘软胶囊(TJSC)对实验性高脂血症大鼠血脂、体内抗氧化系统和血管内皮系统的影响。方法将72只SD雄性大鼠随机分为6组:正常组,模型组,辅酶Q10(CoQ10)对照组,TJSC低、中、高剂量组。每组12只。正常组喂以普通饲料,模型组喂以高脂饲料,其余各组亦喂高脂饲料并分别灌胃不同剂量的TJSC及CoQ10。4周后检测其血脂、抗氧化系统和内皮系统各项指标。结果 TJSC能降低高脂血症大鼠血清胆固醇、甘油三酯、极低密度脂蛋白胆固醇、动脉粥样硬化指数、脂质过氧化物丙二醛和血浆内皮素水平,提高高密度脂蛋白胆固醇与血清胆固醇的比值,并能提高血清超氧化物歧化酶活性及一氧化氮含量。结论 TJSC具有调节高脂血症大鼠血脂代谢、增强其抗氧化系统活力和保护血管内皮系统的作用。

Objective To study the protective effects of Tianji soft capsule（TJSC） on blood lipids,internal antioxidant system and vascular endothelial system in hyperlipidemia rats.Methods Seventy two healthy male rats were divided into six groups.The rats in control group were administered with ordinary diet.The rats in model group were fed with high cholesterol/lipid diet to induce hyperlipidemia.The rats in TJSC and CoQ10 groups were fed with high cholesterol/lipid diet,and treated with TJSC at different doses of 83（low-dose group,L）,250（middle-dose group,M）,750（high-dose group,H） mg/kg,and CoQ10 at the dose of 83 mg/kg,respectively.All animals were put to death after four weeks,effects on lipid level;antioxidant system and endothelial system were evaluated through detection of total cholesterol（TC）,triglyceride（TG）,very low density lipoprotein（VLDL）,atherogenic index（AI）,malondidehyde（MDA） and plasma endothelin（ET）,HDL/TC ratio,activities of superoxide dismutase（SOD） and nitric oxide（NO）.Results Compared with model group,serum TC,TG,VLDL,AI,MDA and ET reduced and the HDL/TC ratio increased,meanwhile activities of SOD and NO were enhanced.Conclusion TJSC can regulate the lipid metabolism,enhance antioxidant system and protect the vascular endothelia system in hyperlipiemic rats.