干扰素治疗丙型肝炎耐药机制的研究进展
摘要
丙型肝炎是临床常见疾病,因其易于慢性化和缺乏有效治疗药物而迁延不愈。干扰素（IFN）是唯一可用的药物,但仅对少数型别和患者有效,其耐药机理尚不完全清楚,现将近年来的研究进展综述如下。 一、HCV膜蛋白E<sub>2</sub>对蛋白激酶的抑制作用 干扰素主要通过刺激基因产物发挥相应的抗病毒效应。IFN刺激产生的抗病毒蛋白有蛋白激酶、磷酸二脂酶。
出处
《实用肝脏病杂志》
CAS
2000年第3期190-191,共2页
Journal of Practical Hepatology
参考文献9
-
1Khorisi H,Castelain S,Wyseur A,et al.Mutation of hepatitis C virus 1b NS5A 2209-2248 amino acid sequence do not predict the response to recombinant interferon-alfa therqpy in French patients. Journal of Hepatology . 1997
-
2Snrrazin C,Berg T,Lee JH,et al.Mutations in the protein kinasebinding domins of the NS5A protein in patients infected with hepatitis C virus type 1a are associated with treatment response. The Journal of Infectious Diseases . 2000
-
3Enomoto N,Sakuna L,Asahina Y,et al.Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. The Journal of Clinical Investigation . 1995
-
4Gale MJ,Tang NM,Tan SL,et al.Evidence that hepatitis C virus resistant to interferon is mediated through repression of the PKR protein kinsse by the nonstructural 5A protein. Journal of Virology . 1997
-
5Taiyuan University of Technology.教学质量保障系统研究的认识与实践[J].教学研究,1999,22(1):55-56. 被引量：1
-
6Enomoto N,Kurosaki M,Marumo F,et al.Fluctuation of hepatitis C virus quasispecie in persistent infection and interferon treatment revealed by single strand comfornation polymerphism analysis. Journal of General Virology . 1994
-
7Polyak SJ,Paschal DM,Mcardie S,et al.Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication. Hepatology . 1999
-
8Enomoto N,Sakuma L,Asahina Y,et al.Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. The New England Journal of Medicine . 1996
-
9Hayashi J,Kishihera Y,Yamajik Y,et al.hepatitis C virus quasispecies and liver damage in patients with chronic hepatitis C virus infection. Hepatology . 1997
-
1鲁国勋,吴新民.干扰素治疗流行性乙型脑炎的疗效[J].湖南医学,1994,11(5):317-317. 被引量：3
-
2俞莹莹,吴勤动.幽门螺杆菌耐药机制研究近况[J].临床内科杂志,2004,21(5):359-360.
-
3马亦林.抗病毒药物治疗慢性肝炎的临床应用[J].浙江预防医学,1995,7(1):8-11. 被引量：1
-
4任姗,陈新月.遗传易感因素与慢性乙型肝炎干扰素治疗反应的相关性[J].国际流行病学传染病学杂志,2008,35(6):403-407.
-
5李维乾,郑元悦.人白细胞α——干扰素治疗流行性乙型脑炎49例疗效观察[J].中国药业,1996,5(6):38-38.
-
6传染病总论[J].传染病网络动态,2004(11):40-45.
-
7熊滨.侵袭性真菌感染诊治进展[J].中国临床新医学,2009,2(5):523-527. 被引量：4
-
8陈龙凤,蒋秀平.新癀片用于干扰素所致发热效果观察[J].中国乡村医药,2012,19(16):35-35.
-
9杜长明.治乙肝不可乱“干扰”[J].医药与保健,2001,0(2):14-14.
-
10李骥.它达拉非和地塞米松降低高海拔肺水肿发生[J].中国医疗前沿,2006,0(A07):92-93.
