干扰素治疗丙型肝炎耐药机制的研究进展
摘要
丙型肝炎是临床常见疾病,因其易于慢性化和缺乏有效治疗药物而迁延不愈。干扰素(IFN)是唯一可用的药物,但仅对少数型别和患者有效,其耐药机理尚不完全清楚,现将近年来的研究进展综述如下。 一、HCV膜蛋白E<sub>2</sub>对蛋白激酶的抑制作用 干扰素主要通过刺激基因产物发挥相应的抗病毒效应。IFN刺激产生的抗病毒蛋白有蛋白激酶、磷酸二脂酶。
出处
《实用肝脏病杂志》
CAS
2000年第3期190-191,共2页
Journal of Practical Hepatology
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