慢性乙型肝炎患者血清HBV DNA含量与肝功能损害程度的关系

IS THE SERUM LEVEL OF HEPATITIS B VIRUS DNA RELATED TO LIVER DAMAGE IN PATIENTS WITH CHRONIC HEPATITIS B?

目的 了解慢性乙型肝炎患者血清HBV DNA含量与肝功能损害程度的关系。方法 应用荧光能量转移定量聚合酶链反应检测233例慢性乙型肝炎患者血清HBV DNA含量。结果 HBeAg阳性患者血清HBV DNA含量(10^(6.18±2.04)拷贝/毫升)显著高于HBeAg阴性/抗-HBe阳性患者的含量(10^(4.16±1.78)拷贝/毫升)(P<0.001);不同ALT水平的慢性乙型肝炎患者血清HBV DNA含量无显著性差异(P>0.05);无黄疸组、轻度黄疸组、中度黄疸组、重度黄疸组的慢性乙型肝炎患者血清HBV DNA含量分别为:(10^(5.56±2.02)拷贝/毫升)、(10^(5.38±1.84)拷贝/毫升)、(10^(5.46±1.92)拷贝/毫升)、(10^(5.34±1.98)拷贝/毫升),四组间无显著性差异(P>0.05)。结论 HBV DNA含量与HBeAg密切相关;病毒复制程度与肝功能损害程度无关。

Objective To study the relationship between the concentration of serum HBVDNA and liver funcon in patients with chronic hepatitis B. Metdods Serum HBVDNA concentration of 233 cases with chronic hepatitis B was detected by quantitative polymerase chain reaction. Results The results showed that (1) The concentration of serum HBVDNA in patients with positve HBeAg was singnificantly higher than that in patients with HBeAg negative or/and anti-HBe positive (P< 0.001). (2) No significant relation was observed between ALT level and serumHBV DNA concentration. (3) No significant difference of HBVDNA con- centration was detected in patients with different serum bilirubin level. Conclusions The concentration of serum HBVDNA was correlated with HBeAg,and had no relationship to the severity of underlying liver diseases. Hepatitis B HBV DNA Quantitative PCR