慢性肝病患者血清转化生长因子β_1水平与肝纤维化的关系

STUDY ON THE RELATIONSHIP BETWEEN SERUM LEVELS OF TRANSFORMING GROWTH FACTOR β_1 IN THE PATIENTS WITH VIRAL HEPATITIS AND LIVER FIBROSIS

目的 探讨血清转化生长因子β_1(TGF-β_1)水平与肝纤维化的关系及在肝纤维化中的诊断价值。方法对139例肝病患者血清采用ELISA法检测TGF-β_1水平,并同时采用放射免疫法检测血清HA、LN、Ⅳ-C等肝纤维化血清学指标。结果 随着病情加重、肝纤维化程度加深,血清TGF-β_1逐渐升高,以肝硬变组最明显;血清TGF-β_1水平与血清HA、LN、Ⅳ-C均呈明显的正相关,且与Ⅳ_C相关更密切。结论 血清TGF-β_1与肝纤维化有密切联系,其血清水平可反映肝纤维化的程度,可作为诊断肝纤维化的一项可靠的新的血清学指标。

Objective To study the relationship between serum levels of transforming growth factor β1(TGF-β1) and hepatofibrosis. Methods The serum levels of TGF-β1 was measured by means of ELISA in 139 cases with viral hepatitis, and hyaluronic acid (HA), laminin (LN),type IV collagen( IV-C)were determined simul by means of RIA. Results The levels of TGF-β1 in the liver cirrhosis group was highest in the liver disease. The serum TGF-β1 was positively correlated with HA,LN and IV-C,especially with IV-C. Conclusion The serum levels of TGF-β1 can reflect the degree of liver firbrosis ,and it can be considered of a new valuable serum component of hepatofibrosis.