乙型肝炎患者中TTV的混合感染

TRANSFUSIDN TRANSMITTED VIRUS INFECIION IN PATIENTS WITH HEPATITIS B

目的 研究乙型肝炎患者合并TTV感染状况及其对乙型肝炎病情的影响。方法 采用斑点杂交法检测乙型肝炎患者血清TTV DNA阳性率。结果 在128例乙型肝炎患者中检出血清TTV DNA阳性者16例(12.5％),在38例急性乙型肝炎患者的阳性率(13.1％)与90例慢性乙型肝炎的阳性率(12.2％)无统计学差异,混合感染TTV对乙型肝炎患者肝功能无明显影响。结论 在北京地区存在TTV感染,但其致病性值得进一步研究。

Objective To investigate transfusion transmitted virus infection in patients with hepatitis B. Methods The serum TTV DNA was detected by dot blot hybridization. Results Out of 128 patients with hepatitis B, 16( 12.5% )patients were positive for serum TTV DNA. There was no statistical difference in TTV DNA positivity between patients with acute and with chronic hepatitis B( 13.1 % vs, 12.2%) ; There was also no statistical difference in degree of liver function damage between hepatitis B patients with and without TTV infection. Conclusion The virulence of TTV is yet to be elucidated.