江门市120例静脉吸毒者HBV、HCV和HGV感染状况

PREVALENCE OF HBV,HCV AND HGV INFECTION IN 120 INTRAVENOUS DRUG ABUSERS IN JIANGMEN CITY

目的 了解静脉毒瘾者乙型肝炎病毒(HBV),丙型肝炎病毒(HCV)及庚型肝炎病毒的感染状况。方法 对广东省江门市120例静脉毒瘾者血浆的HBV、HCV和HGV的标记物进行了检测,采用ELISA法检测HBsAg,HBeAg,抗-HBc,抗-HBe,抗-HBs,抗-HCV;逆转录聚合酶链反应(RT-PCR)检测HGV RNA。结果 120例静脉毒瘾者中HBsAg阳性有13例(10.83％),抗-HBs阳性41例(34.71％),单项抗-HBc阳性7例(5.83％),抗-HCV阳性89例(74.17％),HGV RNA阳性28例(23.33％)。13例HBsAg阳性中9例抗-HCV阳性,3例HGV RNA阳性;7例单项抗-HBc阳性中5例抗-HCV阳性,2例HGV RNA阳性;28例HGV RNA阳性中20例抗-HCV阳性;2例HBsAg、抗-HCV、HGV RNA同时阳性。结论 静脉毒瘾者是HCV和HGV的高危感染人群;HBV,HCV和HGV三种病毒的感染之间在静脉毒瘾者中无相关性。

Objective To investigate the prevalence of hepatitis B virus(HBV) .hepatitis C virus(HCV) and hepatitis,G virus(HGV) in intravenous drug abusers(IVDUs). Methods HBsAg, HBeAg, anti-HBc, anti-HBe,anti-HCV and HGV RNA of HBV,HCV and HGV were detected by enzyme linked immunosorbent assay(ELISA) or reverse transcription polymerase chain reaction(RT-PCR) in 120 IVDUs from Jiangmen City,Guangdong province. Results Of 120 IVDUs, 13(10.83%) were HBsAg positive,41 (34.17%) anti-HBs positive,7(5.83%) single anti-HBc positive,89(74.175) anti-HCV positive,28(23.335)HGV RNA positive. In 13 patients with positive HBsAg,9 were anti-HCV positive and 3 HGV RNA positive. Of 7 cases with single anti-HBc positive, 5 were detected anti-HCV and 2 were detected HGV RNA. 20 of 28 IVDUs with positive HGV RNA were anti-HGV positive. Only 2 IVDUs were HBsAg, anti-HCV, HGV RNA positive together. Conclusion IVDUs were the high risk populaton for HCV and HGV infections. No causal relations were found among HBV,HCV,HGV infections in IVDUs.