摘要
Objective: To discuss the possibility of dexamethasone-dextran as a colon-specific dexamethasone prodrug. Methods: Dexamenthasone-dextran conjugate was synthesized with succinate as a cross-linker. The release of dexamethasone was determined after the incubation of the prodrug with the contents of different parts of gastrointestinal(GI) tract of rats. Results: By HPLC analysis, it was shoWn that dexamethasone-dextran contained 9.2 mg dexamethasone per l00 mg dextran. conjugate. During 160 min incubation, the concentration of dexamethasone released in the contents of colon and cecum was 2.7 times as high as that released in the contents of proximal small intestine and distal small intestine. But no dexametha sone was released in the contents of stomach. Conclusion: Dexamethasone-dextran conjugate can be ed as a colon-specific dexamethasone prodrug to selectively deliver the drug to colon.
Objective: To discuss the possibility of dexamethasone-dextran as a colon-specific dexamethasone prodrug. Methods: Dexamenthasone-dextran conjugate was synthesized with succinate as a cross-linker. The release of dexamethasone was determined after the incubation of the prodrug with the contents of different parts of gastrointestinal(GI) tract of rats. Results: By HPLC analysis, it was shoWn that dexamethasone-dextran contained 9.2 mg dexamethasone per l00 mg dextran. conjugate. During 160 min incubation, the concentration of dexamethasone released in the contents of colon and cecum was 2.7 times as high as that released in the contents of proximal small intestine and distal small intestine. But no dexametha sone was released in the contents of stomach. Conclusion: Dexamethasone-dextran conjugate can be ed as a colon-specific dexamethasone prodrug to selectively deliver the drug to colon.
