Synthesis of Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors-1-(3-Phthalimido-2-oxobutyl)-4-Substituted-phenylpiperazines

Synthesis of Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors-1-(3-Phthalimido-2-oxobutyl)-4-Substituted-phenylpiperazines

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摘要 We have designed and synthesized a series of new phthalimidopiperazines, biological activity test show that the target compounds(Ic, Ie, ii) can inhibit HIV-I RT with IC50 20.0, 43.8, and 63.7 mu M, respectively. We have designed and synthesized a series of new phthalimidopiperazines, biological activity test show that the target compounds(Ic, Ie, ii) can inhibit HIV-I RT with IC50 20.0, 43.8, and 63.7 mu M, respectively.

作者 Xin CHEN Lin WANG Zhi Zhong ZHAO Xing Quan ZHANG Xiang Hong CHEN Hong Shan CHEN(Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050 Institute of Medicinal Biotechnology, Chinese Academy of M

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2000年第7期571-572,共2页 中国化学快报（英文版）

关键词 PIPERAZINE PHTHALIMIDE HIV1-RT inhibitor piperazine phthalimide HIV1-RT inhibitor

分类号 O629 [理学—有机化学]

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1P. C. Jain,et al. Journal of Medicinal Chemistry . 1967
2J. L. Mokrusz,et al. Journal of Medicinal Chemistry . 1994

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Chinese Chemical Letters

2000年第7期

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Synthesis of Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors-1-(3-Phthalimido-2-oxobutyl)-4-Substituted-phenylpiperazines

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