Liquid Chromatographic Resolution of Racemic 2-Phenyl-1,1-cyclopropanedicarbonitrile and its Analogues on Chiral Stationary Phase
Liquid Chromatographic Resolution of Racemic 2-Phenyl-1,1-cyclopropanedicarbonitrile and its Analogues on Chiral Stationary Phase
摘要
Excellent resolution of racemic 2-phenyl-1,1-cyclopropanedicarbonitrile and its nine analogues was accomplished using 100-5CH1-TBB chiral stationary phase under normal-phase HPLC conditions. The influence of mobile phase and the optimum conditions for the resolution of optically active enantiomers were investigated.
Excellent resolution of racemic 2-phenyl-1,1-cyclopropanedicarbonitrile and its nine analogues was accomplished using 100-5CH1-TBB chiral stationary phase under normal-phase HPLC conditions. The influence of mobile phase and the optimum conditions for the resolution of optically active enantiomers were investigated.
基金
National Natural Science Foundation of China
参考文献3
-
1P. Ficarra,R. Ficarra,A. Chimirri,G. Romeo,S. Tommasini,M. L. Calabrò,D. Costantino,A. M. Monforte,M. Carulli.Enantiomeric resolution of anti-HIV agents on a cellulose derivative chiral stationary phase[J].Chromatographia (-).1994(1-2)
-
2Y Okamoto.M.Kawashima.K. Hatada[].Journal of Chromatography.1986
-
3E. R. Francotte,"Chiral Seporations.Applications and Technology’, ed.American ChemicalSociety[].Washington DC.1997
-
1Wei GUO,Zhen Hua SHANG,Yi Nian YU and Liang Mo ZHOU (Dalian Institute of Chemical Physics, Chinese, Academy of Sciences P.O. Box 100, Datian 116012).CELLULOSE MEMBRANE USED AS STATIONARY PHASE OF MEMBRANE AFFINITY CHROMATOGRAPHY[J].Chinese Chemical Letters,1994,5(10):869-872. 被引量：2
-
2Liu Min,Zeng Zhaorui,Ding Yuqiang,Liu Suhuai.The Synthesis of A New Cyclodextrin-Crown Ether Chiral Stationary Phase and Application in Gas Chromatography[J].Wuhan University Journal of Natural Sciences,1998,3(3):83-86.
-
3Xiao Qian HAN,Hui Tao LIU,Jin Zhang GAO,Jing Guo HOU,Chong Yang LI,Guo Hu ZHAO.Enantioseparation of some Racemic Compounds on Cellulose Tris (3,5-dimethylphenylcarbamate) Chiral Stationary Phase[J].Chinese Chemical Letters,2000,11(8):731-734.
-
4Keyword Index to Volume 9 (1991)[J].Chinese Journal of Chemistry,1991,9(6):573-576.
-
5Zi Hui MENG,Liang Mo ZHOU,Qing Hai WANG and Dao Qian ZHU(Dalian Institute of Chewical Physics, Chinese Academy of Sciences, Dalian 116012).Molecular Imprinting of (R)-(+)-α-Methylbenzylamine for Chiral Stationary Phase[J].Chinese Chemical Letters,1997,8(4):345-346. 被引量：1
-
6Zhou, XC,Lu, XR,Wu, CY,Chen, YY.TWO NOVEL EASILY PREPARED CHIRAL POLYSILOXANE STATIONARY PHASES FOR GC RESOLUTION OF ENANTIOMERS[J].Chinese Chemical Letters,1995,6(1):53-54.
-
7Hong WANG,Xiao Yu WANG,Yuan De LONG,Tian Bao HUANG.CHROMATOGRAPHIC SEPARATION OF THE ENANTIOMERS OF 3-PHENYL-1,2-EPOXYETHANE AND 1-PHENYL-1-PROPANOL ON A FUSED SILICA CAPILLARY COLUMN COATED WITH PERBENZYL-β-CYCLODEXTRIN[J].Chinese Chemical Letters,1992,3(11):901-902.
-
8张磊,谢宝竹,阮源萍.1,2-二苯基乙二胺及与脱氢乙酸缩合生成的席夫碱化合物对映体的高效液相色谱法拆分[J].色谱,2006,24(5):531-532. 被引量：1
-
9Yuan De LONG,Xing Wu KANG,Tian Bao HUANG Chengdu Institute of Organic Chemistry, Academia Sinica, Chengdu 610015.A NOVEL DERIVATIVE OF β-CYCLODEXTRIN AS CHIRAL SIATIONARY PHASE IN CAPILLARY GAS CHROMATOGRAPHY[J].Chinese Chemical Letters,1992,3(6):457-458.
-
10ZHOU,Liang-Mo LOU,Xian-Wen SHENG,Yu-Fong WANG,Qing-Hai ZHU,Dao-Qian Dalian Institute of Chemical Physics,Academia Sinica,Dalian116012.A crosslinked chiral stationary phase for the separation of enantiomers by gas and supercritical fluid chromatography[J].Chinese Journal of Chemistry,1991,9(4):322-326.
